Background: In the context of contaminated land, assessing risk involves identifying a source, a pathway and a receptor. We describe how this approach worked in practice following the discovery of high lead levels in the soil of an allotment site in a London borough.
Methods: Soil and produce analyses were undertaken. A worst-case scenario was constructed to estimate the maximum potential lead intake by consumers. A questionnaire survey was undertaken of individuals who either worked on the allotment or ate significant amounts of produce grown on it. They were also offered blood lead tests.
Results: High lead levels were found in soil and produce. The worst-case assessment showed that the estimated lead intake by a hypothetical consumer of allotment produce exceeded the provisional tolerable weekly intake almost 10-fold. Further tests on produce indicated that soil contamination had contributed to the high lead levels. The questionnaire survey did not reveal any chronic illness related to lead exposure. Of the five tested, none had raised blood lead levels.
Conclusions: A decision was made to remediate the site. Pending this, we advised the allotment holders not to cultivate the land or eat any produce grown on it as we could not be sure that preparation of the produce before consumption would remove all adherent lead-contaminated soil, and continued cultivation could also expose them to lead in the soil dust.
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http://dx.doi.org/10.1093/pubmed/22.4.525 | DOI Listing |
BMC Cardiovasc Disord
January 2025
Department of Cardiology, Northern Jiangsu People's Hospital, Nantong West Road No. 98, Yangzhou, Jiangsu, 225001, China.
Objectives: The aim of this study was to explore the correlation between blood test indicators and Atrial Fibrillation (AF) in Individuals Aged 65 and Older in Yangzhou, Jiangsu.
Methods: From January 1, 2019, to August 31, 2023, an epidemiological cross-sectional survey was conducted among the elderly population undergoing health check-ups at Northern Jiangsu People's Hospital in Jiangsu Province. Patients diagnosed with AF after a 12-lead electrocardiogram were included in the case group, and non-AF individuals matched by age and gender in a 1:4 frequency ratio were included in the control group.
J Transl Med
January 2025
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing, 100730, China.
Background: Immunotherapy is a significant risk factor for severe COVID-19 in multiple myeloma (MM) patients. Understanding how immunotherapies lead to severe COVID-19 is crucial for improving patient outcomes.
Methods: Human protein microarrays were used to examine the expression of 440 protein molecules in MM patients treated with bispecific T-cell engagers (BiTe) (n = 9), anti-CD38 monoclonal antibodies (mAbs) (n = 10), and proteasome inhibitor (PI)-based regimens (n = 10).
Cardiovasc Revasc Med
January 2025
Weatherhead PET Imaging Center, Division of Cardiology, Department of Medicine, McGovern Medical School at UTHealth and Memorial Hermann Hospital, Houston, TX, United States of America.
Patients with angina but without obstructive epicardial coronary disease still require a specific mechanistic diagnosis to enable targeted treatment. The overarching term "coronary microvascular dysfunction" (CMD) has been applied broadly - but is it correct? We present a series of case examples culminating a systematic exploration of our large clinical database to distinguish among four categories of coronary pathophysiology. First, by far the largest group of "no stenosis angina" patients exhibits subendocardial ischemia during intact flow through diffuse epicardial disease during dipyridamole vasodilator stress.
View Article and Find Full Text PDFNeurol Med Chir (Tokyo)
January 2025
Department of Neurosurgery, Tohoku University Graduate School of Medicine.
Pediatric patients with moyamoya disease frequently show rapid progression with a high risk of stroke. Indirect revascularization is widely accepted as a surgical treatment for pediatric moyamoya disease, but it does not augment cerebral blood flow immediately, which leaves patients at risk for stroke peri-operatively. This delay in flow augmentation may make adding direct bypass the better option.
View Article and Find Full Text PDFJ Gastrointest Surg
January 2025
Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Introduction: Cystic echinococcosis is a widely endemic helminthic disease caused by infection with metacestodes (larval stage) of the Echinococcus granulosus tapeworm, which is transmitted by dogs and found on every continent except Antarctica. We sought to review the life cycle, epidemiology, symptoms, diagnostic methods, and treatment of Echinococcus granulosus of the liver.
Methods: A comprehensive review was conducted using Medline/PubMed, Google Scholar, Cochrane Library, and the Web of Science accessed between 1990 and 2024.
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