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Predictors of response to low-dose amitriptyline for irritable bowel syndrome and efficacy and tolerability according to subtype: post hoc analyses from the ATLANTIS trial.
Gut
January 2025
Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK
Background: Low-dose amitriptyline, a tricyclic antidepressant (TCA), was superior to placebo for irritable bowel syndrome (IBS) in the AmitripTyline at Low-dose ANd Titrated for Irritable bowel syndrome as Second-line treatment (ATLANTIS) trial.
Objective: To perform post hoc analyses of ATLANTIS for predictors of response to, and tolerability of, a TCA.
Design: ATLANTIS randomised 463 adults with IBS to amitriptyline (232) or placebo (231).
Fatigue relief in multiple sclerosis by personalized neuromodulation: A multicenter pilot study [FaremusGE].
Mult Scler Relat Disord
January 2025
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy; Ospedale Policlinico San Martino - IRCCS, Genoa, Italy.
Background: A recent application of the GRADE guidelines indicated Faremus, a 5-day neuromodulation for 15 min per day via transcranial direct current stimulation (tDCS), as medium to highly recommendable for alleviating fatigue in multiple sclerosis (MS).
Methods: With this pilot study we aimed to evaluate the feasibility, acceptance, safety, and effectiveness of the Faremus treatment carried out in a multicenter context. The Rome unit prepared the intervention, supplied the personalized electrodes to the San Martino Hospital in Genova, where the neurological team enrolled the population of fatigued people with multiple sclerosis (PwMS) and carried out the treatment.
Let's talk about class: A peer-to-peer social class workshop for psychotherapy trainees.
Psychotherapy (Chic)
January 2025
Department of Counseling and Human Development, University of Louisville.
There is a growing consensus that effective psychotherapists and counselors require antioppressive, social-justice-oriented, culturally and structurally responsive training (e.g., Neville et al.
View Article and Find Full Text PDFReflections on using methodology to engage with Pacific youth in Aotearoa New Zealand about their sexual and reproductive health.
Sex Reprod Health Matters
January 2025
Researcher Associate, "Let's talk about it! Project"; Research Officer, School of Public Health and Interdisciplinary Studies, Faculty of Health and Environmental Studies, Auckland University of Technology, Auckland, New Zealand.
Pacific understandings of sexual and reproductive health (SRH) encompass beliefs and practices reflective of Pacific values systems. These are integral to cultural understandings of safety, relationships, and intimacy. Research processes and practices that appropriately address these values and sensitives are scarcely available in the literature, leading to limited use and understanding of culturally appropriate methods and procedures.
View Article and Find Full Text PDFDrop the bias, design prospective randomized studies, use the SVP classification system, and let's try to get some real answers!
J Vasc Surg Venous Lymphat Disord
January 2025
Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, MA.
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