The penetration of the lipophilic model permeant, 1-cyanodecane, into isolated human stratum corneum (SC) was followed nondestructively by step-scan Fourier transform infrared (FTIR) photoacoustic spectroscopy (PAS) with phase modulation technique. The uptake of the compound in the SC was quantified by monitoring the alterations in the spectra in the course of the penetration using multivariate analysis. Step-scan technique in conjunction with phase modulation offers the possibility for controllable depth profiling (sampling depth up to 30 microm) during the penetration process. Based on Fick's second law and assuming a virtually layered structure of the membrane, depth-dependent diffusion coefficients were derived by numerical fitting of the spectroscopic data. For 1-cyanodecane, the diffusion coefficient in the inner region of the SC is 1.6-fold that measured in the outer region.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0168-3659(00)00371-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Whole-brain gray matter volume and fractional anisotropy of the posterior thalamic radiation and sagittal stratum in healthy adults correlate with the local environment.
Neuroimage
January 2025
Open Innovation Institute, Kyoto University, Kyoto, Japan; Graduate School of Management, Kyoto University, Kyoto, Japan; Institute of Innovative Research, Tokyo Institute of Technology, Meguro, Tokyo, Japan; ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), Chiyoda, Tokyo, Japan; Office for Academic and Industrial Innovation, Kobe University, Kobe, Japan; Brain Impact, Kyoto, Japan.
The impacts of air pollution, local climate, and urbanization on human health have been well-documented in recent studies. In this study, we combined magnetic resonance imaging (MRI) brain analysis with a questionnaire survey on the local environment in 141 healthy middle-aged men and women. Our findings reveal that a favorable environment is positively correlated with gray matter volume (GMV) in the frontal and occipital lobes, cerebellum, and whole brain, as well as with fractional anisotropy (FA) in the fornix (including the fornix stria terminalis), posterior thalamic radiation (PTR), sagittal stratum (SS), and whole brain.
View Article and Find Full Text PDFResearch Progress of Microneedles in Vaccine Delivery.
Curr Med Chem
January 2025
Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan, 250000, China.
Large-scale infectious diseases have become a significant threat to human health and safety. The successful invention of vaccines is the most powerful means for preventing infectious diseases and has greatly improved global human health. Even during the pandemic of COVID-19, which has affected the world, vaccines have played an irreplaceable role.
View Article and Find Full Text PDFInnovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing.
Pharmaceutics
December 2024
School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand.
Skin ageing, driven predominantly by oxidative stress from reactive oxygen species (ROS) induced by environmental factors like ultraviolet A (UVA) radiation, accounts for approximately 80% of extrinsic skin damage. L-glutathione (GSH), a potent antioxidant, holds promise in combating UVA-induced oxidative stress. However, its instability and limited penetration through the stratum corneum hinder its topical application.
View Article and Find Full Text PDFCharacteristics of Hydrogels as a Coating for Microneedle Transdermal Delivery Systems with Agomelatine.
Molecules
January 2025
School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.
Agomelatine (AGM) is an effective antidepressant with low oral bioavailability due to intensive hepatic metabolism. Transdermal administration of agomelatine may increase its bioavailability and reduce the doses necessary for therapeutic effects. However, transdermal delivery requires crossing the barrier.
View Article and Find Full Text PDFEstablishing a General Atomistic Model for the Stratum Corneum Lipid Matrix Based on Experimental Data for Skin Permeation Studies.
Int J Mol Sci
January 2025
Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology (IIT) Delhi, New Delhi 110016, India.
Understanding the permeation of drugs through the intercellular lipid matrix of the stratum corneum layer of skin is crucial for effective transdermal delivery. Molecular dynamics simulations can provide molecular insights into the permeation process. In this study, we developed a new atomistic model representing the multilamellar arrangement of lipids in the stratum corneum intercellular space for permeation studies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!