The MICs of evernimicin at which 90% of Borrelia burgdorferi patient isolates were inhibited ranged from 0.1 to 0.5 microg/ml. Evernimicin was as effective as ceftriaxone against B. burgdorferi in a murine model of experimental Lyme disease. As assessed by culturing the urinary bladders of infected C3H mice, no live Borrelia isolates were recoverable following antibiotic treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC90397 | PMC |
| http://dx.doi.org/10.1128/AAC.45.3.936-937.2001 | DOI Listing |
Publication Analysis
Top Keywords
lyme disease
8
efficacy evernimicin
4
evernimicin sch27899
4
sch27899 vitro
4
vitro animal
4
animal model
4
model lyme
4
disease mics
4
mics evernimicin
4
evernimicin 90%
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!