Plant-parasitic nematodes transmit viruses that hit hard on global agriculture. Both the nematodes and the viruses they carry persist in the soil for a long time with the only remedy being highly toxic chemicals. Fundamental new research may offer the hope of developing safer control strategies.
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Knowledge and attitude towards Herpes Simplex Virus-2 in Al-Jouf region, Saudi Arabia.
J Infect Dev Ctries
December 2024
Faculty of Medicine, Alexandria National University, Egypt.
Introduction: Herpes simplex virus type-2 (HSV-2) infection is a sexually transmitted disease (STD) that causes genital ulcers. The prevalence of HSV-2 increases because of its asymptomatic shedding. This study aimed to evaluate community knowledge and attitude toward HSV-2 infection in Al-Jouf region.
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Virus Evol
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Department of Microbiology and Immunology, McGill University, 3775 University Street Montreal, QC H3A 2B4, Canada.
Infectious disease transmission to different host species makes eradication very challenging and expands the diversity of evolutionary trajectories taken by the pathogen. Since the beginning of the ongoing COVID-19 pandemic, SARS-CoV-2 has been transmitted from humans to many different animal species, in which viral variants of concern could potentially evolve. Previously, using available whole genome consensus sequences of SARS-CoV-2 from four commonly sampled animals (mink, deer, cat, and dog), we inferred similar numbers of transmission events from humans to each animal species.
View Article and Find Full Text PDFSTI/HIV risk prediction model development-A novel use of public data to forecast STIs/HIV risk for men who have sex with men.
Front Public Health
January 2025
School of Mathematics, Physics and Computing, Centre for Health Research, University of Southern Queensland, Toowoomba, QLD, Australia.
A novel automatic framework is proposed for global sexually transmissible infections (STIs) and HIV risk prediction. Four machine learning methods, namely, Gradient Boosting Machine (GBM), Random Forest (RF), XG Boost, and Ensemble learning GBM-RF-XG Boost are applied and evaluated on the Demographic and Health Surveys Program (DHSP), with thirteen features ultimately selected as the most predictive features. Classification and generalization experiments are conducted to test the accuracy, F1-score, precision, and area under the curve (AUC) performance of these four algorithms.
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ACS Infect Dis
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Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.
Soil-transmitted helminth (STH) infections affect one-fourth of the global population and pose a significant threat to human and animal health, with limited treatment options and emerging drug resistance. (whipworm) stands out as a neglected disease, necessitating new drugs to address this unmet medical need. We discovered that several different chemical series of related human Provirus Integration sites for Moloney murine leukemia virus (PIM) family kinase inhibitors possess potent anthelmintic activity by using whole-worm motility assays.
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