Preamble: The veterinary profession regulation describes veterinary surgeons as being the appointed protectors of animals. In accordance with this principle, the "Veterinary Association for the protection of Animals" has put together some guidelines to assist members of the veterinary profession in their work with respect to the welfare and protection of animals. This issue of the "Codex veterinarius" is not a description of the present situation. It is rather meant to be a guide for the future, to be understood as a self-binding commitment. All members of the veterinary profession must, due to their specific knowledge, be committed to improve and enhance the protection of animals. When in doubt they should decide in favour of the animal, which, however, does not imply a higher ranking of animals. Veterinary surgeons should not assist in intensifying the productive use of animals out of purely economical interests, without taking on the ethical responsibility for the animal as a living creature, capable of suffering. The "Veterinary Association for the Protection of Animals" calls upon all veterinary surgeons to adopt the hereby described principles. Principles: Veterinary surgeons have a particular ethical responsibility for animals as living beings able to suffer. Veterinary action for the welfare and protection of animals is guided by the principle of respect for life and the awareness that the animal has a dignity which is to be respected. Therefore protection and care for an animal can not be dependent on its economical value. In situations of diverting interests between moral obligations and economical pressure it is essential to consider carefully the respect for life against the productive use of life in all its forms of existence. The ethical concept of justice for human beings as well as for animals requires that equal entities, according to their equality, are to be valued and treated equally, and unequal entities according to their inequality are to be valued and treated differently (principle of equality). Considering carefully the opposing interests and needs, the interests of the human being should not automatically be considered to be more important than those of the animal. Prior to any interference with the physical and psychological integrity of the animal the veterinary surgeon has to question herself/himself to which extent her/his intervention is morally justified. When in doubt veterinary surgeons should let themselves be guided by the principle: In dubio pro animale!
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Lancet Neurol
January 2025
Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK. Electronic address:
The blood-brain barrier is a physiological barrier that can prevent both small and complex drugs from reaching the brain to exert a pharmacological effect. For treatment of neurological diseases, drug concentrations at the target site are a fundamental parameter for therapeutic effect; thus, the blood-brain barrier is a major obstacle to overcome. Novel strategies have been developed to circumvent the blood-brain barrier, including CSF delivery, intracranial delivery, ultrasound-based methods, membrane transporters, receptor-mediated transcytosis, and nanotherapeutics.
View Article and Find Full Text PDFBiomedicines
January 2025
Department of Biotechnology, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan.
Thiadiazine thione (THTT) has gained significant interest owing to its pharmacological potentials, particularly its antiparasitic and anti-inflammatory properties. Leishmaniasis is a clinical syndrome caused by infection with species and is associated with an inflammatory response and nociception. The available treatments against leishmaniasis are inadequate, as they are associated with high cost, toxicity, and increased resistance.
View Article and Find Full Text PDFJ Am Vet Med Assoc
January 2025
7Royal Veterinary College, University of London, Hatfield, UK.
Objective: The aim of this study was to report the outcome and prognosis of canine patients treated medically or surgically for rectal plasmacytomas and to identify factors associated with recurrence, mortality, or progression to multiple myeloma.
Methods: The databases of 7 referral hospitals were reviewed. The Kaplan-Meier method and Cox proportional hazards analysis were used to determine the association of a range of variables with recurrence and progression-free interval for the surgically treated patients.
Ann Anat
January 2025
Department of Anatomy, Ankara University School of Medicine, Ankara, Turkey. Electronic address:
Background: This study aims to demonstrate the 3-dimensional pattern of the nutrient vessels of the triquetrum using micro-computed tomography and determine the safe region for screw applications to the bone.
Methods: Seven fresh frozen cadavers' ulnar and radial arteries were injected with Microfil MV-117. Triquetral bones were dissected and examined using micro-computed tomography.
J Clin Invest
January 2025
Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, United States of America.
Colorectal cancer (CRC) remains a leading cause of cancer death due to metastatic spread. LIN28B is overexpressed in 30% of CRCs and promotes metastasis, yet its mechanisms remain unclear. In this study, we genetically modified CRC cell lines to overexpress LIN28B, resulting in enhanced PI3K/AKT pathway activation and liver metastasis in mice.
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