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Spectrum and the management of glanular-preputial adhesions after ritual male circumcision.
BMC Urol
December 2024
Pediatric Surgery Dept, Al-Azhar university, Cairo, Egypt.
Background: Complications after male circumcision are numerous and may be presented as an adhesion between the glans penis and the preputial remnants, these adhesions may acquire different forms and troublesome the affected children.
Patients And Methods: This is a retrospective study of 95 consecutive children of presumed glanular-preputial adhesions referred for correction of circumcision. They were assessed and classified as having either an early preputial adhesion or a well-formed skin bridge into 2 groups; group (A) who have a simple adhesion that was resolved through a conservative preputial adhesiolysis while those in the group (B) had a well-formed skin bridge, which deserves surgical correction.
A Novel Urological Application of Hyaluronic Acid/Alginate Sheet to Prevent Adhesion Formation: A Technique Guide and Case Series.
Cureus
December 2024
Orthopaedic Surgery, Maimonides Medical Center, Brooklyn, USA.
Tissue gliding and mobility are paramount to the success of penile procedures. While postoperative healing is intended to protect, repair, and nourish injured tissues, an overzealous response often leaves painful and debilitating tethering between the corpora, including nerves, and surrounding tissues. This tethering interferes with the intended outcomes of surgery by preventing necessary gliding.
View Article and Find Full Text PDFNectin-4 Positivity in Genitourinary Malignancies: A Systematic Review.
JCO Precis Oncol
December 2024
Department of Medical Oncology, IRCCS San Raffaele Hospital, Milan, Italy.
Article Synopsis
- - The study investigates the expression of nectin-4 (N4) in various genitourinary (GU) cancers, particularly focusing on its relevance as a potential target for antibody-drug conjugates, given its aberrant expression in malignancies like urothelial carcinoma of the bladder (UBC).
- - A systematic review analyzed 25 studies on N4 positivity across different GU tumors, finding that N4 positivity is generally higher in bladder cancers, especially in metastatic and non-muscle-invasive stages, compared to other types like upper tract urothelial carcinoma and non-urothelial cancers.
- - The findings suggest that non-urothelial malignancies have lower rates of N4 positivity compared to bladder cancer,
Acanthus Condom Catheter: A Reusable and Adjustable Silicone Male External Catheter With Pressure-Sensitive Silicone Adhesive for Urinary Drainage.
Cureus
September 2024
Engineering, Skinister Medical, Woodland, USA.
Condom catheters are also called external urinary collection devices to collect urine and monitor urine output in hospitalized and other patients with urinary incontinence. They play an important role in reducing catheter-associated urinary tract infections by using invasive indwelling catheters that are placed inside the bladder. Currently, male external catheters come with or without adhesives.
View Article and Find Full Text PDFNLRP3 inhibitor combined with Yimusake improves erectile dysfunction in rats with diabetes mellitus through the attenuation of pyroptosis.
Heliyon
October 2024
Department of Human Anatomy, School of Basic Medical Science, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, 830011, China.
Erectile dysfunction (ED) is a prevalent complication associated with diabetes mellitus (DM), yet pharmacological treatments for diabetes-related erectile dysfunction (DMED) continue to be inadequate in clinical settings. Our previous studies have indicated that there is a close correlation between ED and pyroptosis, but the specific mechanism remains unclear. In this study, we sought to explore the therapeutic effects of DMED through the modulation of NLRP3, aiming to elucidate its potential molecular mechanisms.
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