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Colloid-Forming Prodrug-Hydrogel Composite Prolongs Lower Intraocular Pressure in Rodent Eyes after Subconjunctival Injection.
Adv Mater
January 2025
Department of Chemical Engineering & Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.
Colloidal drug aggregates (CDAs) are challenging in drug discovery due to their unpredictable formation and interference with screening assays. These limitations are turned into a strategic advantage by leveraging CDAs as a drug delivery platform. This study explores the deliberate formation and stabilization of CDAs for local ocular drug delivery, using a modified smallmolecule glaucoma drug.
View Article and Find Full Text PDFTherapeutic Potential of Dimethyl Sulfoxide Subconjunctival Injection in a Diabetic Retinopathy Rat Model.
In Vivo
December 2024
Laboratory of Veterinary Ophthalmology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic for Korea
Background/aim: Diabetic retinopathy (DR), a complication of diabetes, causes damage to retinal blood vessels and can lead to vision impairment. Persistent high blood glucose levels contribute to this damage, and despite ongoing research, effective treatment options for DR remain limited. Dimethyl sulfoxide (DMSO) has shown anti-inflammatory and antioxidant properties in both in vivo and in vitro studies; however, its potential as an anti-inflammatory agent in the context of DR has not yet been explored.
View Article and Find Full Text PDFPeribulbar vs. incisionless sub-Tenon's blocks: a retrospective cohort study.
Eur J Med Res
December 2024
Department of Anesthesiology and Reanimation, Faculty of Medicine, Osmangazi University, Büyükdere Mh, Odunpazarı, 26040, Eskişehir, Turkey.
Background: Ophthalmic procedures are increasingly being performed under regional anesthesia techniques such as peribulbar and incisionless sub-Tenon's blocks. The aim is to compare peribulbar block with incisionless sub-Tenon's block in terms of perioperative complications in patients who underwent cataract and vitreoretinal surgeries.
Methods: The patients who underwent cataract or vitroretinal surgery under peribulbar block or incisionless sub-Tenon's block were included in the study.
Retrobulbar Hematoma: Presentation, Management, and Visual Outcomes.
J Craniofac Surg
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Division of Plastic and Reconstructive Surgery, R. Adams Cowley Shock Trauma Center.
Retrobulbar hematoma (RH) is a diagnostic and therapeutic emergency that may cause permanent vision loss. Lateral canthotomy and cantholysis (LCC) is typically performed when IOP is elevated or vision is compromised. The authors describe the outcomes of the largest cohort of patients with RH to date.
View Article and Find Full Text PDFEyelid Ecchymoses and Subconjunctival Hemorrhage in Pertussis.
N Engl J Med
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University Children's Hospital, Zurich, Switzerland
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