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Intracellular dark endothelial spots detected using specular microscopy are associated with graft failure after Descemet's membrane endothelial keratoplasty.
Graefes Arch Clin Exp Ophthalmol
January 2025
Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.
Purpose: To investigate the correlation between intracellular dark endothelial spots (IDESs) detected by specular microscopy and the incidence of graft failure after Descemet's membrane endothelial keratoplasty (DMEK).
Methods: We reviewed 100 consecutive DMEK patients performed by a single surgeon at two centres between January 2015 and July 2022. Central corneal thickness was evaluated using anterior segment optical coherence tomography (SS-1000; Tomey, Aichi, Japan), and endothelial cell density was measured using specular microscopy.
Atypical Leber Hereditary Optic Neuropathy (LHON) Associated with a Novel MT-CYB:m.15309T>C(Ile188Thr) Variant.
Genes (Basel)
January 2025
Eye Hospital, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.
The study presents a detailed examination and follow-up of a Slovenian patient with an Leber Hereditary Optic Neuropathy (LHON)-like phenotype and bilateral optic neuropathy in whom genetic analysis identified a novel variant :m.15309T>C (Ile188Thr). We provide detailed analysis of the clinical examinations of a male patient with bilateral optic neuropathy from the acute stage to 8 years of follow-up.
View Article and Find Full Text PDFSensitive ratiometric detection of Fumonisin B using a reusable Ag-pSi SERS platform.
Food Chem X
January 2025
Institute of Agricultural Engineering, ARO, Volcani Institute, Rishon LeZion, Israel.
Food and agricultural commodities endure consistent contamination by mycotoxins, low molecular weight fungal metabolites, which pose severe health implications to humans together with staggering economic losses. Herein, a ratiometric aptasensor was constructed using silver-coated porous silicon (Ag-pSi) used as an efficient surface-enhanced Raman scattering (SERS) substrate. The bioassay included direct detection of fumonisin B (FB), an abundant and widespread contaminant, by a specific aptamer sequence immobilized on the porous transducer.
View Article and Find Full Text PDFThe effect of L-carnitine supplementation on anthropometric and malnutrition status in acute ischemic stroke patients: a triple-blinded randomized clinical trial.
BMC Nutr
January 2025
Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Background: Malnutrition is a significant challenge in stroke patients, affecting both rehabilitation and independence. This study aims to evaluate whether early L-carnitine supplementation can effectively improve anthropometric parameters and malnutrition status in acute-phase ischemic stroke patients to mitigate the catabolic state.
Methods: Eighty-two first-ever ischemic stroke patients were randomly assigned to either the L-carnitine group (1000 mg three times/day for seven consecutive days) or the matching placebo group.
Evaluation of Tele-Education in Malawi for Detection of Macular Features Using Optical Coherence Tomography.
Klin Monbl Augenheilkd
January 2025
Department of Ophthalmology, University Hospital Tübingen, Germany.
Purpose: The study aimed to assess the reliability of tele-education in training a Malawian ophthalmology resident to interpret optical coherence tomography (OCT) images of patients with macular conditions.
Methods: This was a retrospective analysis of 1000 macula-centered OCT image series from 1000 eyes of 1000 consecutive patients from Malawi, which involved initial interpretation by a German retina specialist (observer 1) (T). Observer 1 then trained a Malawian resident (observer 2) via email, and observer 2 independently interpreted images at T, followed by face-to-face training in Malawi and reinterpretation at T and T (3-month intervals).
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