J Vis Exp
November 2019
Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital; Children's National Heart Institute, Children's National Hospital; Department of Pediatrics, Department of Pharmacology & Physiology, School of Medicine and Health Sciences, George Washington University;
Small animal models are most commonly used in cardiovascular research due to the availability of genetically modified species and lower cost compared to larger animals. Yet, larger mammals are better suited for translational research questions related to normal cardiac physiology, pathophysiology, and preclinical testing of therapeutic agents. To overcome the technical barriers associated with employing a larger animal model in cardiac research, we describe an approach to measure physiological parameters in an isolated, Langendorff-perfused piglet heart.
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