A rat model of hypereosinophilic syndrome.

Pathol Int

Department of Laboratory Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.

Published: February 2001

AI Article Synopsis

  • A study was conducted on a specific type of rat, Matsumoto Eosinophilia Shinshu (mes), which naturally develops hypereosinophilia (an elevated level of eosinophils) without any chemical or antigen treatment starting at 9 weeks old.
  • The rats exhibited inflammatory lesions in several organs, including aortitis and granulomatous lesions, characterized by the infiltration of eosinophils and macrophages, along with crystal deposits associated with eosinophil-specific proteins.
  • While the tissue damage observed in mes differs slightly from human hypereosinophilic syndrome (HES), the similarities suggest that mes may serve as a useful model for understanding the disease's pathogenesis and associated tissue injuries.

Article Abstract

Hypereosinophilia-occurring rats without chemical and antigen treatment have been maintained in our laboratory. The rat, Matsumoto Eosinophilia Shinshu (mes), showed hypereosinophilia at the age of 9 weeks or older and developed eosinophil-related inflammatory lesions in many organs. These lesions included: aortitis, granulomatous lesion in the mesenteric lymph node, inflammatory fibroid polyp of the stomach and pulmonary vasculitis with septal infiltration. These lesions were involved with cellular infiltration of eosinophils and macrophages, and deposition of eosinophilic crystals which immunohistologically showed major basic protein and eosinophilic peroxidase derived from eosinophilic lysosomal constituents. Although the distribution of lesions in mes is a little different from that of hypereosinophilic syndrome (HES) in humans, in that endomyocardial fibrosis appears in HES while aortitis appears in mes, mes is probably comparable with HES. The present paper describes the pathological aspects of the lesions in mes and discusses the pathogenesis of tissue injury related to eosinophilic infiltration.

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Source
http://dx.doi.org/10.1046/j.1440-1827.2001.01175.xDOI Listing

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