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Prevalence of metabolic syndrome and its components in Iran: an updated meta-analysis.
BMC Endocr Disord
January 2025
Social Determinants of the Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Background: Considering, the changes in lifestyle during the last decade the main aim of this study was to investigate the pooled prevalence of metabolic syndrome (MetS) and its components in Iran.
Methods: For implementing a comprehensive search strategy related to the objectives of the present meta-analysis, all international databases like PubMed (Medline), Scopus, Embase, Web of Sciences (Elsevier), and CINHAL were searched up to January 2024. The quality of the final selected studies was evaluated according to the Joanna Briggs Institute Critical Appraisal (JBI) tool for analytical cross-sectional studies.
Identifying preeclampsia-associated key module and hub genes via weighted gene co-expression network analysis.
Sci Rep
January 2025
Department of Gynaecology and Obstetrics, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu, China.
Preeclampsia (PE) is a common hypertensive disease in women with pregnancy. With the development of bioinformatics, WGCNA was used to explore specific biomarkers to provide therapy targets efficiently. All samples were obtained from gene expression omnibus (GEO), then we used a package named "WGCNA" to construct a scale-free co-expression network and modules related to PE.
View Article and Find Full Text PDFExploring the potential association between serum selenium and hypertension in obese adult males in the United States.
Sci Rep
January 2025
Department of Gastroenterology of Shenzhen Second People's Hospital, Health Science Center, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, People's Republic of China.
Previous studies on the correlation between serum selenium and hypertension have yielded inconsistent results. Our previous analysis of participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2018 indicated that elevated serum selenium concentrations were associated with an increased risk of metabolic abnormalities in obese individuals, with the primary effect being on blood pressure in males. The aim of this study was to further elucidate the relationship between serum selenium and the risk of hypertension in obese males.
View Article and Find Full Text PDFTryptophan metabolism-related gene CYP1B1 serves as a shared biomarker for both Parkinson's disease and insomnia.
Sci Rep
January 2025
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Dong Road, Zhengzhou, Henan, China.
Parkinson's disease (PD) and insomnia are prevalent neurological disorders, with emerging evidence implicating tryptophan (TRP) metabolism in their pathogenesis. However, the precise mechanisms by which TRP metabolism contributes to these conditions remain insufficiently elucidated. This study explores shared tryptophan metabolism-related genes (TMRGs) and molecular mechanisms underlying PD and insomnia, aiming to provide insights into their shared pathogenesis.
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