Arenavirus nucleocapsid protein displays a transcriptional antitermination activity in vivo.

Virus Res

Instituto de Bioquímica y Biología Molecular, Depto. de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Buenos Aires, Argentina.

Published: January 2001

RNA polymerase pausing and transcriptional antitermination regulates gene activity in several systems. In arenavirus infected cells the switch from transcription to replication is subjected to a hairpin-dependent termination and requires protein synthesis to bypass this signal. The transcriptional antitermination control by Junín virus nucleocapsid protein N, has been demonstrated in vivo by infecting BHK-21 cells expressing this viral protein in the presence of translation inhibitors. This is the first demonstration in vivo of a transcriptional antitermination control in arenavirus-infected cells.

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http://dx.doi.org/10.1016/s0168-1702(00)00222-7DOI Listing

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