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Recombinant Expression of a New Antimicrobial Peptide Composed of hBD-3 and hBD-4 in Escherichia coli and Investigation of Its Activity Against Multidrug-Resistant Bacteria.
Probiotics Antimicrob Proteins
January 2025
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, No. 20 Dongda Street, Beijing, 100071, Fengtai District, China.
Human β-defensin (HBD) has been recognized as a promising antimicrobial agent due to its broad-spectrum antimicrobial activity against various pathogens. In our previous work, we engineered a chimeric human β-defensin, designated H4, by fusing human β-defensin 3 and human β-defensin 4, resulting in enhanced antimicrobial activity and salt stability. However, the high cost of chemical synthesis due to the relatively large number of amino acids in H4 has limited its applications.
View Article and Find Full Text PDFMolecular mechanism of Yersinia ruckeri Flagellin C (FliC) induced intestinal inflammation in channel catfish (Ictalurus punctatus).
Comp Biochem Physiol B Biochem Mol Biol
January 2025
Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. Electronic address:
Yersinia ruckeri is known to cause enteric red mouth disease (ERM) in channel catfish (Ictalurus punctatus). This study first established a model of Y. ruckeri-induced intestinal inflammation in channel catfish.
View Article and Find Full Text PDFInvestigating Subpopulation Dynamics in Clonal CHO-K1 Cells with Single-Cell RNA Sequencing.
J Biotechnol
January 2025
Johns Hopkins Biomedical Engineering; Johns Hopkins University Department of Molecular Biology and Genetics, Baltimore, Maryland, USA; Johns Hopkins University Department of Medicine, Division of Infectious Disease, Baltimore, Maryland, USA. Electronic address:
Chinese Hamster Ovary (CHO) cells produce monoclonal antibodies and other biotherapeutics at industrial scale. Despite their ubiquitous nature in the biopharmaceutical industry, little is known about the behaviors of individual transfected clonal CHO cells. Most CHO cells are assessed on their stability, their ability to produce the protein of interest over time.
View Article and Find Full Text PDFCloning and functional verification of gene in .
PeerJ
January 2025
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Background: Geraniol 10-hydroxylase (G10H) is a cytochrome P450 monooxygenase involved in regulation, which is involved in the biosynthesis of monoterpene. However, G10H is not characterized at the enzymatic mechanism and regulatory function in .
Methods And Results: A gene related to the biosynthesis of monoterpenoid, geraniol 10-hydroxylase, has been cloned from the medicinal plant .
Evolution and Functional Diversification of Serine Racemase Homologs in Bacteria.
J Mol Evol
January 2025
Department of Plant and Soil Sciences, 311 Plant Science Building, University of Kentucky, Lexington, KY, 40546-0312, USA.
Amino acid racemases catalyze the interconversion of L- and D-amino acids, maintaining intracellular levels of both D- and L-amino acids. While alanine and glutamate racemases are widespread in bacteria, serine racemase (SerR) is predominantly found in animals. Recently, homologs of animal SerR were reported in some bacterial genomes, but their evolutionary distribution and functional roles remain poorly understood.
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