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Parapsoriasis-A Diagnosis with an Identity Crisis: A Narrative Review.

Dermatol Ther (Heidelb)

May 2022

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

Article Synopsis
  • Parapsoriasis is a rare inflammatory skin disease that manifests as chronic patches and can be resistant to treatment, with its classification evolving significantly over the past 120 years.
  • It is now mainly categorized into small plaque parapsoriasis (SPP) and large plaque parapsoriasis (LPP), although there is ongoing debate regarding nomenclature among experts.
  • The condition can progress to cutaneous lymphoma, making accurate diagnosis challenging, and due to its rarity, there is a lack of substantial clinical guidelines, which this comprehensive review aims to address by discussing various aspects of the disease and proposing a differentiation scheme from early-stage mycosis fungoides (MF).
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Background: Poikilodermatous mycosis fungoides (pMF) is characterized by poikiloderma areas, typically involving the major flexural areas and trunk. Its presentation can be generalized or admixed with other forms of MF. Previous studies fail to correlate the clinical presentation with prognosis and laboratory findings.

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