AI Article Synopsis
- The study investigates how growth hormone (GH) levels decline with age and its potential link to aging and age-related traits.
- The researchers used DNA chip technology to analyze gene expression changes in the livers of aging rats, finding significant effects on various metabolic processes.
- Their results indicated that GH replacement therapy normalized the expression of about 40% of the genes affected by aging, providing insights into GH's role in improving metabolism and body composition.
Article Abstract
The mechanisms that control life span and age-related phenotypes are not well understood. It has been suggested that aging or at least some of its symptoms are related to a physiological decline in GH levels with age. To test this hypothesis, and to improve our understanding of the cellular and molecular mechanisms behind the aging process, we have analyzed age-induced changes in gene expression patterns through the application of DNA chip technology. In the present study, the aging process was analyzed in rat liver in the presence or absence of GH replacement. Out of 3,000 genes printed on the microarrays, approximately 1,000 were detected in the rat liver. Among these, 47 unique transcripts were affected by the aging process in male rat livers. The largest groups of age-regulated transcripts encoded proteins involved in intermediary metabolism, mitochondrial respiration, and drug metabolism. Approximately 40% of the differentially expressed gene products were normalized after GH treatment. The majority of those transcripts have previously not been shown to be under GH control. The list of gene products that showed normalized expression levels in GH-treated old rats may shed further insight on the action and mechanism behind the positive effects of GH on, for example, fuel metabolism and body composition observed in different animal and human studies.
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| http://dx.doi.org/10.1210/mend.15.2.0594 | DOI Listing |
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