Background: Small intestinal bacterial overgrowth may contribute to the development of non-alcoholic steatohepatitis, perhaps by increasing intestinal permeability and promoting the absorption of endotoxin or other enteric bacterial products.
Aims: To investigate the prevalence of small intestinal bacterial overgrowth, increased intestinal permeability, elevated endotoxin, and tumour necrosis factor alpha (TNF-alpha) levels in patients with non-alcoholic steatohepatitis and in control subjects.
Patients And Methods: Twenty two patients with non-alcoholic steatohepatitis and 23 control subjects were studied. Small intestinal bacterial overgrowth was assessed by a combined (14)C-D-xylose and lactulose breath test. Intestinal permeability was assessed by a dual lactulose-rhamnose sugar test. Serum endotoxin levels were determined using the limulus amoebocyte lysate assay and TNF-alpha levels using an ELISA.
Results: Small intestinal bacterial overgrowth was present in 50% of patients with non-alcoholic steatosis and 22% of control subjects (p=0.048). Mean TNF-alpha levels in non-alcoholic steatohepatitis patients and control subjects were 14.2 and 7.5 pg/ml, respectively (p=0.001). Intestinal permeability and serum endotoxin levels were similar in the two groups.
Conclusions: Patients with non-alcoholic steatohepatitis have a higher prevalence of small intestinal bacterial overgrowth, as assessed by the (14)C-D-xylose-lactulose breath test, and higher TNF-alpha levels in comparison with control subjects. This is not accompanied by increased intestinal permeability or elevated endotoxin levels.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1728215 | PMC |
http://dx.doi.org/10.1136/gut.48.2.206 | DOI Listing |
J Surg Case Rep
January 2025
NYU Langone Hospital - Long Island, 259 1st St, Mineola, NY 11501, United States.
Internal herniation through the foramen of Winslow (FoW) is a rare, life-threatening diagnosis. We present a case of intestinal obstruction due to herniation of the ileum, cecum, appendix, and ascending colon through the FoW. We reduced the herniation using a small colotomy and preserved the entirety of the bowel.
View Article and Find Full Text PDFJ Toxicol Environ Health A
January 2025
School of Public Health, Hengyang Medical School, University of South China, Hengyang, China.
The global phenomenon of cyanobacterial bloom pollution is spreading globally due to climate change and eutrophication. It is well established that harmful cyanobacteria produce a wide range of toxins including microcystin-LR (MC-LR), a cyclic heptapeptide toxin known to damage various organs. The intestinal tract is the main site of MC-LR absorption and one of the targets susceptible to toxicity.
View Article and Find Full Text PDFSci Rep
January 2025
Department of General Surgery, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
The use of Santulli enterostomy (SE) for necrotizing enterocolitis (NEC) has been limited to a small number of studies involving a small number of patients and no control group. Our study aimed to compare the clinical safety and efficacy of Santulli enterostomy with those of single- or double-lumen enterostomy for neonatal NEC through a retrospective cohort study. One hundred ten patients who met the criteria were divided into an SE group (64 patients) and a conventional enterostomy (CE) group (46 patients).
View Article and Find Full Text PDFBMJ Case Rep
January 2025
General Surgery, Whipps Cross University Hospital NHS Trust, London, UK.
Intra-abdominal lymphangioma, a rare benign lymphatic malformation resulting from an obstruction to lymphatic channels, often has non-specific clinical manifestations. Low incidence rates of this condition, paired with its unusual presentation and ambiguous radiological appearance, commonly lead to diagnostic uncertainty. This pathology can result in significant morbidity and mortality, emphasising the need to achieve early diagnosis and management despite these challenges.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Northern Beaches Hospital, Frenchs Forest, New South Wales, Australia.
Littré hernia is the rare protrusion of a Meckel's diverticulum (MD) through a hernia sac. We present a rare case of strangulated MD in a woman patient in her 90s, which required a small intestine resection. She presented with 1 day of groin swelling, no features of bowel obstruction and an irreducible hernia on examination.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!