An increasing amount of evidence suggests that the pathophysiology of schizophrenia is associated with activation of the inflammatory response system, as indicated by lower serum concentrations of Clara cell secretory protein (CC16), an endogenous anti-inflammatory protein in patients with schizophrenia. In the present study, we investigated the genetic association between a functional polymorphism (A38G) in human CC16 gene and schizophrenia (248 Japanese schizophrenic patients and 206 healthy controls). No significant positive association between the CC16 gene polymorphism and schizophrenia was observed. In addition, even when schizophrenic patients were divided into those with a positive family history for schizophrenia and with a negative family history for schizophrenia, no significant association with A38G polymorphism of the CC16 gene was observed. Our results suggest that the CC16 gene polymorphism do not confer increased susceptibility for schizophrenia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0304-3940(00)01707-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Antimicrobial resistance, virulence gene profiles, and molecular epidemiology of enterococcal isolates from patients with urinary tract infections in Shanghai, China.
Microbiol Spectr
January 2025
Department of Laboratory Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Unlabelled: Urinary tract infections (UTIs) are among the most prevalent infectious diseases, yet there is still limited understanding of the epidemiology of Enterococcal strains isolated from UTI patients in Shanghai. This study aims to elucidate the antimicrobial resistance profiles, virulence gene carriage, and molecular epidemiology of selected Enterococcal strains from UTI patients in Shanghai. A cohort of 80 and 40 clinical isolates were randomly selected from UTI patients from October 2022 to March 2023.
View Article and Find Full Text PDFExtracellular Vesicle-Encapsulated microRNAs and Respiratory Health Among American Indian Participants in the Strong Heart Study.
Chest
January 2025
Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY.
Background: American Indian populations have experienced marked disparities in respiratory disease burden. Extracellular vesicle-encapsulated microRNAs (EV-miRNAs) are a novel class of biomarkers that may improve recognition of lung damage in indigenous populations in the United States.
Research Question: Are plasma EV-miRNAs viable biomarkers of respiratory health in American Indian populations?
Study Design And Methods: The Strong Heart Study is a prospective cohort study that enrolled American Indian patients aged 45 to 74 years.
Botanical formulation HX110B ameliorates PPE-induced emphysema in mice via regulation of PPAR/RXR signaling pathway.
PLoS One
July 2024
R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul, Korea.
Chronic obstructive pulmonary disease (COPD), an inflammatory lung disease, causes approximately 3 million deaths each year; however, its pathological mechanisms are not fully understood. In this study, we examined whether HX110B, a mixture of Taraxacum officinale, Dioscorea batatas, and Schizonepeta tenuifolia extracts, could suppress porcine pancreatic elastase (PPE)-induced emphysema in mice and its mechanism of action. The therapeutic efficacy of HX110B was tested using a PPE-induced emphysema mouse model and human bronchial epithelial cell line BEAS-2B.
View Article and Find Full Text PDFAnalysis of molecular epidemiological characteristics and antimicrobial susceptibility of vancomycin-resistant and linezolid-resistant Enterococcus in China.
BMC Med Genomics
July 2024
Hangzhou xixi Hospital, Hangzhou, Zhejiang, 310023, China.
Background: This study investigates the distribution and characteristics of linezolid and vancomycin susceptibilities among Enterococcus faecalis (E. faecalis) and Enterococcus faecium (E. faecium) and explores the underlying resistance mechanisms.
View Article and Find Full Text PDFInvestigation of lactotransferrin messenger RNA expression levels as an anti-type 2 asthma biomarker.
J Allergy Clin Immunol
September 2024
Samuel Bronfman Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Medicine, Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, Ariz. Electronic address:
Article Synopsis
- Lactotransferrin (LTF) is linked to asthma susceptibility due to its role in immune regulation, prompting research on LTF mRNA levels as a potential biomarker for type 2 (T2) asthma.
- The study analyzed LTF mRNA expression in human bronchial epithelial cells, finding that lower levels correlate with increased asthma severity, exacerbations, and reduced lung function, alongside heightened airway T2 inflammation markers.
- The results suggest that low LTF expression could serve as an indicator for distinguishing between eosinophilic and neutrophilic asthma, positioning LTF as a promising target for asthma diagnostics and management.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!