The methodology of assessing adherence to sleep restriction therapy for insomnia has received little attention in the empirical literature. The present study proposes and evaluates several approaches to assessing adherence to sleep restriction. We investigated multiple methods of measuring adherence and tested their utility by determining the strength of their association with treatment outcome in a sample of 22 older adults with insomnia (16 women, six men). As a group, the measures indicated reasonably good adherence to treatment recommendations. Time spent in bed was significantly reduced at post-treatment, and the night to night consistency of time spent in bed and arising time was significantly greater at post-treatment. However, time spent in bed per night at post-treatment still exceeded therapist recommendations by a mean of 27.89 min (SD=31.72). Greater consistency of time spent in bed per night and a more consistent arising time predicted a better treatment outcome. Measures of degree of bedtime reduction did not predict treatment outcome.
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http://dx.doi.org/10.1016/s0005-7967(00)00002-4 | DOI Listing |
Behav Ecol
December 2024
Centre for Ecology and Conservation, University of Exeter, Treliever Road, Penryn, Cornwall TR10 9FE, United Kingdom.
Outcomes of theoretical models on conflict resolution between investing partners in bi-parental care systems typically predict "partial compensation" or "matched" response rules, depending on underlying assumptions. Further, although experimental tests in birds suggest that care levels by pair members are largely associated with partial compensation responses, this outcome partly depends on the type of experiment used and its effects on model assumptions. To elucidate support for both the underlying assumptions and predictions of models predicting partner compensation versus matching, we performed temporary, bi-directional brood size manipulations during late nestling provisioning in blue tits () in the French Pyrenees.
View Article and Find Full Text PDFiScience
January 2025
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.
Post-comatose disorders of consciousness (DoC) represent persistent neurological conditions with limited therapeutic options and a poor prognosis. Recent works advocate for exploring the effects of psychedelics to enhance brain complexity in DoC and ameliorate their consciousness. We investigated sub-anesthetic concentration of the atypical psychedelic ketamine for treating post-comatose prolonged DoC through a double-blind, placebo-controlled, cross-over trial involving three adult patients.
View Article and Find Full Text PDFObjective: Our objective of this study was to analyse all oncological clinical trials using regorafenib to create a complete risk/benefit profile for the drug.
Background: Creating a novel chemotherapy is costly both in time and capital spent for drug manufacturers. To regenerate what they've spent, drug manufacturers may attempt to repurpose their medications for new indications via clinical trials.
Psychiatry Investig
January 2025
Department of Biomedical Sciences, Center for Glocal Future Biomedical Scientists at Chonnam National University, Gwangju, Republic of Korea.
Objective: This study aims to investigate may moesin deficiency resulted in neurodevelopmental abnormalities caused by negative impact on synaptic signaling ultimately leading to synaptic structure and plasticity.
Methods: Behavioral assessments measured neurodevelopment (surface righting, negative geotaxis, cliff avoidance), anxiety (open field test, elevated plus maze test), and memory (passive avoidance test, Y-maze test) in moesin-knockout mice (KO) compared to wild-type mice (WT). Whole exome sequencing (WES) of brain (KO vs.
BMC Public Health
January 2025
Centre for Prevention, Lifestyle and Health, National Institute for Public Health and The Environment, Bilthoven, The Netherlands.
Background: A new paradigm of hybrid working exists, with most office workers sharing their work between the office and home office environment. Working from home increases time spent or prolonged sitting, which is associated with an increased risk of chronic disease. Interventions to reduce sitting time, specifically designed for both the office and home-office environments, are required to address this growing public health issue.
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