AI Article Synopsis
- Activity-dependent decreases in extracellular spike amplitude reduce the effectiveness of action potentials back-propagating into dendrites of hippocampal pyramidal cells.
- The study shows that this attenuation happens during behavior and lessens as animals gain experience in their environment.
- The findings indicate that experience influences neural coupling and relies on NMDA receptors, suggesting that behavioral plasticity can change the properties of hippocampal pyramidal cells.
Article Abstract
Activity-dependent attenuations in extracellular spike amplitude have been shown to correlate with a decrease in the effectiveness with which somatic action potentials back-propagate into the dendritic arbor of hippocampal pyramidal cells. In this paper we demonstrate that activity-dependent attenuations in amplitude occur during behavior and that the amount of attenuation is reduced with an animal's experience in an environment. The observed reductions are caused by an animal's experience within a specific environmental context, are dependent on functional NMDA receptors, and are accompanied by an increase in the effective coupling of pyramidal cells and interneurons. These results provide an important step in linking together in vivo studies with in vitro data and suggest that mechanisms of plasticity engaged during behavior may be sufficient to alter the biophysical and integrative properties of hippocampal pyramidal cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762418 | PMC |
| http://dx.doi.org/10.1523/JNEUROSCI.21-01-00240.2001 | DOI Listing |
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