The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1212/wnl.56.1.127 | DOI Listing |
Publication Analysis
Top Keywords
synaptic proteins
12
altered expression
4
synaptic
4
expression synaptic
4
proteins occurs
4
occurs early
4
early progression
4
progression alzheimer's
4
alzheimer's disease
4
disease expression
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!