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The paper presents the results of using the current multifocal studies of visual functions in patients with various diseases of the retina (detachment, tapetoretinal abiotrophy, macular foramen). It provides evidence for the high correlation of changes detectable in these patients by statistical computer-assisted perimetry and multifocal electroretinography. The implication of comprehensive application of these techniques to the diagnosis and differential diagnosis of ocular neurosensory apparatus diseases and to the functional monitoring and evaluation of treatment has been ascertained.
View Article and Find Full Text PDFMeasurement of non-heme iron in the sera of patients with peripheral tapetoretinal abiotrophy aged 10-72 years with stages I-IV of the disease showed a statistically significant (26-30%) decrease of this parameter in comparison with healthy controls. Total iron-binding capacity of the serum was unchanged. The results are discussed with regard for previous reports about changed iron homeostasis in animals with hereditary retinal degeneration (Campbell rats) and the role of iron in the development and formation of nervous tissues.
View Article and Find Full Text PDFThe threshold spatial contrast sensitivity was assessed in children with amblyopia, tapetoretinal abiotrophy, and partial atrophy of the optic nerve of different origin. The measurements were carried out at spatial frequencies of 0.5-22 cycle/grad.
View Article and Find Full Text PDFClinical and immunologic examinations of 120 patients with central tapetoretinal abiotrophy, central serous choriopathy, central choroiditis, endogenic uveitis, thrombosis of the central retinal vein have revealed deviations in the T and B immunity systems and in autoimmune reactions to retinal S antigen, to uveopigmented antigens, and to human hepatic intracellular lipoprotein, as against the controls. The findings evidenced an imbalance of the T and B immunity parameters: reduced counts of T lymphocytes, theophylline-sensitive T suppressors, elevated immunoregulatory cell index, increased counts of B lymphocytes, circulating immune complexes, and blood serum immunoglobulins A and G. No essential shifts in leukocyte adhesion and antibody-dependent K cell cytotoxicity were found.
View Article and Find Full Text PDFRelative informative value of various functional methods of investigation was studied in 87 patients with tapetoretinal abiotrophy and complicated cataracts in order to find adequate methods for the assessment of the retinal status before surgery and to define the criteria of visual function prediction. The efficacy of the diagnosis was verified after cataract extraction in these patients. The methods of investigation employed were instrumental electroretinogram (ERG) recording, Hanz-Feld stimulated microERG, high-frequency (40 Hz) rhythmic ERG, electrocoagulograms, determination of electric sensitivity thresholds for the retina and of the optic nerve axial bundle lability (ESL), perimetry, and vision acuity measurements.
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