There is an often noted lack of research in the field of disorders of arithmetic skills. The present study assessed the prevalence in both an urban and a rural population sample of German schoolchildren, using standardized academic achievement tests. Eight school classes of third graders in each area were examined (n = 181,182; respectively). We found that 6.6 % (n = 12) of the rural and 6.59 % (n = 12) of the urban school children performed significantly worse in arithmetic than in their spelling tests. Since the diagnostic criteria for the Specific disorder of arithmetical skills and their significance are widely discussed, we attempted in a second step of the study to validate the diagnosis of the Specific disorder of arithmetical skills from a neuropsychological and medical viewpoint. For the validation we assessed clinical data, imaging and neurophysiologic studies as well as a neuropsychological test battery. Nine and five of the children, respectively, were available for this further evaluation. Although the majority of these probands (n = 10) had distinct arithmetic deficits, only three of them met the full diagnostic criteria of the ICD-10 for a Specific disorder of arithmetic skills. In a last step, we compared the data of both studies. Our data strongly support a thorough cliniconeurological, neuropsychological and academic assessment of students with a suspected Specific disorder of arithmetic skills. The current diagnostic criteria should be reconsidered and possibly modified towards a more psychopathologic definition. We stress the need that the condition becomes better known among all professions concerned with the care of children, as difficulties with acquiring arithmetic skills should be detected and approached appropriately as early as possible. The imperative demand of future empiric research is emphasized.
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Biosens Bioelectron
January 2025
Department of Physics, Virginia Commonwealth University, Richmond, VA, 23284, USA; Institute for Sustainable Energy and Environment, Virginia Commonwealth University, Richmond, VA, 23284, USA. Electronic address:
Wearable devices designed for the somatosensory system aim to provide event-cue feedback electronics and therapeutic stimulation to the peripheral nervous system. This prompts a neurological response that is relayed back to the central nervous system. Unlike virtual reality tools, these devices precisely target peripheral mechanoreceptors by administering specific stimuli.
View Article and Find Full Text PDFBiosens Bioelectron
January 2025
Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, Shanghai, 200237, China; School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang, 832000, China. Electronic address:
RNA imaging technology is essential for understanding the complex RNA regulatory mechanisms and serves as a powerful tool for disease diagnosis. However, conventional RNA imaging methods often require multiple fluorescent tags for the specific labeling of individual targets, complicating both the imaging process and subsequent analysis. Herein, we develop an RNA sensor that integrates a blocked CRISPR RNA (crRNA)-based conformational switch with a controllable CRISPR activation (CRISPRa) system and apply for RNA imaging.
View Article and Find Full Text PDFJMIR Mhealth Uhealth
January 2025
Calydial, Vienne, France.
Background: The use of telemonitoring to manage renal function in patients with chronic kidney disease (CKD) is recommended by health authorities. However, despite these recommendations, the adoption of telemonitoring by both health care professionals and patients faces numerous challenges.
Objective: This study aims to identify barriers and facilitators in the implementation of a telemonitoring program for patients with CKD, as perceived by health care professionals and patients, and to explore factors associated with the adoption of the program.
Neurology
February 2025
Schools of Pharmacy and Public Health Sciences, University of Waterloo, Ontario, Canada.
Background And Objectives: Peripartum mood and anxiety disorders constitute the most frequent form of maternal morbidity in the general population, but little is known about peripartum mental illness in mothers with multiple sclerosis (MS). We compared the incidence and prevalence of peripartum mental illness among mothers with MS, epilepsy, inflammatory bowel disease (IBD), and diabetes and women without these conditions.
Methods: Using linked population-based administrative health data from ON, Canada, we conducted a cohort study of mothers with MS, epilepsy, IBD, and diabetes and without these diseases (comparators) who had a live birth with index dates, defined as 1 year before conception, between 2002 and 2017.
Sickle cell disease (SCD) is the most common genetic disease in the world and a societal challenge. SCD is characterized by multi-organ injury related to intravascular hemolysis. To understand tissue-specific responses to intravascular hemolysis and exposure to heme, we present a transcriptomic atlas in the primary target organs of HbSS vs HbAA transgenic SCD mice.
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