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Background: Postradiotherapy nasopharyngeal necrosis with granulation mass (PRNN-GM) is a rare subtype of postradiotherapy nasopharyngeal necrosis (PRNN). It is characterized by the formation of isolated granulomatous tissue masses or masses combined with PRNN. However, the relationship between clinical features and survival outcomes in PRNN-GM remains unclear.
View Article and Find Full Text PDFRisk prediction for elderly cognitive impairment by radiomic and morphological quantification analysis based on a cerebral MRA imaging cohort.
Eur Radiol
January 2025
Institute of PLA Geriatric Medicine, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Objective: To establish morphological and radiomic models for early prediction of cognitive impairment associated with cerebrovascular disease (CI-CVD) in an elderly cohort based on cerebral magnetic resonance angiography (MRA).
Methods: One-hundred four patients with CI-CVD and 107 control subjects were retrospectively recruited from the 14-year elderly MRA cohort, and 63 subjects were enrolled for external validation. Automated quantitative analysis was applied to analyse the morphological features, including the stenosis score, length, relative length, twisted angle, and maximum deviation of cerebral arteries.
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Alzheimers Dement
December 2024
Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Cerebral arterial dilatation, signifying outward vascular remodeling, is linked to a higher risk of Alzheimer's disease and a higher burden of white matter hyperintensities (WMH). Arterial dilatation may disrupt cerebral hemodynamics and lead to delayed blood arrival to the brain, which is itself linked to an increased burden of WMH. We examined if arterial dilatation was associated with blood arrival timing and if blood arrival timing mediated the effect of arterial dilatation on WMH burden.
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Alzheimers Dement
December 2024
Erasmus University Medical Center, Rotterdam, Netherlands.
Background: Increasing evidence shows a link between arterial calcification in the heart-brain axis and cognitive performance. However, how calcification relates to acceleration of cognitive changes, and which specific cognitive domains are mostly affected, remains unclear. We assessed the impact of calcification in major arteries between the heart and brain on cognitive decline and focused on different cognitive domains.
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Alzheimers Dement
December 2024
Erasmus University Medical Center, Rotterdam, Netherlands.
Background: Arteriosclerosis is linked to an increased risk of dementia and Alzheimer's disease. However, the underlying pathological mechanisms remain unclear. We investigated the association between intracranial arteriosclerosis and cerebral Amyloid beta (Aß).
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