AI Article Synopsis
- The article examines how cancer cells develop resistance to treatments for metastatic ovarian cancer, covering both biochemical and clinical aspects.
- It looks at the history of chemosensitivity testing, which helps determine how sensitive cancer cells are to drugs.
- Lastly, the article proposes a new investigational protocol for improving chemosensitivity testing in clinical settings.
Article Abstract
This article reviews the cellular mechanisms that confer biochemical and clinical resistance to antineoplastic agents used in the adjunctive treatment and palliation of metastatic ovarian cancer. The historical development of in vitro chemosensitivity testing is also reviewed, along with published experiences of various investigators with assays used in clinical ovarian cancer treatment programs. Finally, an investigational protocol for chemosensitivity testing is proposed.
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| http://dx.doi.org/10.1007/s11912-999-0014-6 | DOI Listing |
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