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The Abbreviated Methacholine Challenge Test is Safe for Children.
J Pediatr
January 2025
Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheba, Israel.
Objective: To evaluate the safety of an abbreviated methacholine challenge test (MCT) protocol in children.
Study Design: This prospective, observational study enrolled children aged 6 through 18 years referred for the MCT. The abbreviated protocol was initiated with a methacholine dose of 0.
Effects of increasing tidal volume and end-expiratory lung volume on induced bronchoconstriction in healthy humans.
Respir Res
August 2024
Dipartimento di Medicina Sperimentale, Università di Genova, 16132, Genova, Italy.
Background: Increasing functional residual capacity (FRC) or tidal volume (V) reduces airway resistance and attenuates the response to bronchoconstrictor stimuli in animals and humans. What is unknown is which one of the above mechanisms is more effective in modulating airway caliber and whether their combination yields additive or synergistic effects. To address this question, we investigated the effects of increased FRC and increased V in attenuating the bronchoconstriction induced by inhaled methacholine (MCh) in healthy humans.
View Article and Find Full Text PDFImpact of Ongoing Treatment With Inhaled Corticosteroids During Specific Inhalation Challenges for Diagnosing Occupational Asthma.
J Allergy Clin Immunol Pract
November 2024
Chest Department, CIUSSS du Nord-de-l'île-de-Montréal, Montréal, QC, Canada; Chest Department, Université de Montréal, Montréal, QC, Canada. Electronic address:
Background: Specific inhalation challenge (SIC) tests are still the reference test for diagnosing sensitizer-induced occupational asthma (SIOA). The European Respiratory Society recommends the cessation of inhaled corticosteroids (ICS) 72 hours before SIC.
Objective: To assess the effect of an ongoing ICS treatment during SIC on the maximum fall in forced expiratory volume in 1 second (FEV), the change in methacholine provocative concentration of methacholine inducing a 20% fall in FEV (PC), and sputum eosinophil counts after exposure to the suspected agent.
Desmopressin nasal spray inhibiting parasympathetic function on isolated tracheal smooth muscle.
Int J Med Sci
July 2024
Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Nocturia with or without asthma is one of the aging diseases. Desmopressin has been used as a nasal spray for patients who are suffering from nocturia. This study determined the effects of desmopressin on isolated tracheal smooth muscle .
View Article and Find Full Text PDFSalbutamol Easyhaler provides non-inferior relief of methacholine induced bronchoconstriction in comparison to Ventoline Evohaler with spacer: A randomized trial.
Respir Med
June 2024
Allergy Centre, Tampere University Hospital, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Article Synopsis
- Salbutamol is a key medication for treating acute asthma symptoms, typically delivered via a metered-dose inhaler, while dry powder inhalers (DPIs) like Salbutamol Easyhaler are being studied for effectiveness in bronchoconstriction.
- This trial involved 180 participants who experienced significant asthma symptoms after a methacholine challenge, comparing Salbutamol Easyhaler with the standard pMDI with spacer and Budesonide-formoterol Easyhaler.
- Results showed that Salbutamol Easyhaler is just as effective as the pMDI with spacer for relieving bronchoconstriction, suggesting it is a reliable and safe option for asthma attacks.
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