Study Objective: To assess the impact of substituting noninvasive diagnostic studies for Swan-Ganz catheter (SGC) placement in the evaluation of acutely ill patients.
Design: Modified decision analysis.
Methods: Using published studies that define effectiveness of clinical examination, echocardiography, and SGC placement to diagnose pulmonary edema, an analysis of the impact of substituting three diagnostic approaches using (1) clinical assessment (CA), (2) M-mode two-dimensional transthoracic echocardiography (EC), or (3) CA then EC if necessary for SGC placement was considered.
Study Population: Patients with acute respiratory distress and radiographic findings of pulmonary edema, and ICU patients with hypotension and/or pulmonary edema without acute cardiac ischemia.
Interventions: Three approaches using noninvasive studies were substituted for placement of SGC in the initial evaluation of pulmonary edema.
Measurements And Results: The number of SGCs placed, the number of tests needed to diagnose (NTND) all cases of volume overload, and the total number of procedure-related adverse events were calculated for each diagnostic approach and compared to SGC placement. EC, and CA then EC approaches produced fewer procedure-related serious complications and deaths, compared to the SGC approach; however, these approaches also produced a higher NTND and total procedures performed than did the SGC or CA approaches. The CA approach led to reduced NTND and procedure-related adverse events.
Conclusions: Substituting noninvasive studies for SGC placement in the initial evaluation of acutely ill patients may slightly reduce procedure-related adverse events, but it may also increase the number of procedures performed. Studies of SGC use are warranted and need to include a clinical assessment control group and an analysis of resource utilization.
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http://dx.doi.org/10.1378/chest.118.6.1709 | DOI Listing |
Brain Sci
October 2020
Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht University, Room G.02.531, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
In deaf subjects using a cochlear implant (CI) for hearing restoration, the auditory nerve is subject to degeneration, which may negatively impact CI effectiveness. This nerve degeneration can be reduced by neurotrophic treatment. Here, we compare the preservative effects of the naturally occurring tyrosine receptor kinase B (TrkB) agonist brain-derived neurotrophic factor (BDNF) and the small-molecule TrkB agonist 7,8,3'-trihydroxyflavone (THF) on the auditory nerve in deafened guinea pigs.
View Article and Find Full Text PDFInt J Crit Illn Inj Sci
December 2019
Department of Internal Medicine, Maimonides Medical Center, New York, NY, USA.
Latex-induced anaphylactic reactions are often underestimated in patients having procedures in a catheterization lab, intensive care units, or in operating rooms. Most physicians are not aware that almost all balloons in the Swan-Ganz catheter (SGC) are made up of latex. Direct exposure of these latex balloons in the blood can cause severe anaphylactic reactions, even in patients with no previous history of allergies.
View Article and Find Full Text PDFClin Orthop Relat Res
September 2019
S. G. Cone, E. P. Lambeth, M. B. Fisher, Department of Biomedical Engineering, North Carolina State University and the University of North Carolina - Chapel Hill, Raleigh, NC, USA S. G. Cone, J. A. Piedrahita, M. B. Fisher, Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA H. Ru, Department of Computational Biology and Bioinformatics, North Carolina State University, Raleigh, NC, USA L. A. Fordham, Department of Radiology, University of North Carolina - Chapel Hill, Chapel Hill, NC, USA J. A. Piedrahita, Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA J. T. Spang, M. B. Fisher, Department of Orthopaedics, University of North Carolina - Chapel Hill, Chapel Hill, NC, USA.
Background: ACL injuries are becoming increasingly common in children and adolescents, but little is known regarding age-specific ACL function in these patients. To improve our understanding of changes in musculoskeletal tissues during growth and given the limited availability of pediatric human cadaveric specimens, tissue structure and function can be assessed in large animal models, such as the pig.
Questions/purposes: Using cadaveric porcine specimens ranging throughout skeletal growth, we aimed to assess age-dependent changes in (1) joint kinematics under applied AP loads and varus-valgus moments, (2) biomechanical function of the ACL under the same loads, (3) the relative biomechanical function of the anteromedial and posterolateral bundles of the ACL; and (4) size and orientation of the anteromedial and posterolateral bundles.
Acta Crystallogr D Struct Biol
March 2017
Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, England.
The steady expansion in the capacity of modern beamlines for high-throughput data collection, enabled by increasing X-ray brightness, capacity of robotics and detector speeds, has pushed the bottleneck upstream towards sample preparation. Even in ligand-binding studies using crystal soaking, the experiment best able to exploit beamline capacity, a primary limitation is the need for gentle and nontrivial soaking regimens such as stepwise concentration increases, even for robust and well characterized crystals. Here, the use of acoustic droplet ejection for the soaking of protein crystals with small molecules is described, and it is shown that it is both gentle on crystals and allows very high throughput, with 1000 unique soaks easily performed in under 10 min.
View Article and Find Full Text PDFJ Vasc Access
November 2015
1 Cardiac Surgery Intensive Care Unit, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Trieste - Italy.
Purpose: In cardiac surgery, Swan-Ganz catheter (SGC) is often necessary and is inserted before the intervention through an introducer catheter. Catheter-related thrombosis (CRT) is a frequent complication of this procedure and often remains subclinical. The aims of this prospective cohort study were to determinate the incidence of CRT after positioning an SGC through an introducer and to identify factors relating to their occurrence.
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