Digitalis use in children: an uncertain future.

The therapeutic indications for digoxin in the treatment of children with large left-to-right shunts continue to be reassessed. New insights into the alterations in cardiac function imposed by this hemodynamic burden have shown preserved systolic performance. Pharmacological interventions that improve cardiac output by afterload reduction or other modalities have proven useful and potentially have low risk for serious toxicity. Early and successful surgical treatment of most conditions causing pulmonary overcirculation has shortened the duration of medical management and prevented many of the untoward complications of this pathology. As new agents are forthcoming to treat various cardiac conditions, use-by-tradition of cardiac glycosides has appropriately diminished. While the understanding of complicated molecular aspects of cation transport have been enhanced by the unique actions of cardiac glycosides, their clinical utility has decreased. This report summarizes studies on the use of cardiac glycosides in the treatment of large left-to-right shunts in children.