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Exploring Reverse Sural Flap Necrosis in Lupus-like Syndrome: Challenges and Strategies in Lower Limb Reconstruction-A Case Presentation.
Medicina (Kaunas)
December 2024
Plastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081 Salerno, Italy.
Soft tissue reconstruction in the lower limbs presents a significant challenge, particularly when addressing defects in the distal third of the leg, ankle, and foot. The reverse sural flap reliant on the perforating branches of the peroneal artery has emerged as a versatile option, offering a solution for patients for whom microsurgical techniques are not feasible. Despite its advantages, the procedure carries inherent risks, especially in populations with underlying conditions, such as venous insufficiency, cardiovascular disease, and diabetes, as well as in elderly patients, where the likelihood of flap necrosis is elevated.
View Article and Find Full Text PDFRole of STING Deficiency in Amelioration of Mouse Models of Lupus and Atherosclerosis.
Arthritis Rheumatol
November 2024
National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland.
Objective: Systemic lupus erythematosus (SLE) is a systemic autoimmune syndrome characterized by autoreactive responses to nucleic acids, dysregulation of the type I interferon (IFN-I) pathway, and accelerated atherosclerosis. The stimulator of IFN genes (STING), a cytosolic DNA sensor, has pathogenic implications in various inflammatory diseases. However, its specific role in SLE pathogenesis, particularly in tissue damage, remains unclear.
View Article and Find Full Text PDFA Case of a Rheumatoid Arthritis Patient on Newly Initiated Tumor Necrosis Factor Inhibitor Treatment Developing Granulomatosis With Polyangiitis Vasculitis: A Conundrum About Disease Overlap or Drug-Induced Vasculitis.
Cureus
October 2024
Internal Medicine/Rheumatology, University of Florida College of Medicine - Jacksonville, Florida, USA.
Granulomatosis with polyangiitis (GPA) is a necrotizing vasculitides subset of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAVs) that involves small-sized arteries affecting multisystemic organs. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammatory polyarthritis involving the small joints. GPA and RA can have overlapping clinical presentations, including vasculitis, ocular inflammation, interstitial lung disease, and arthritis, but existing evidence indicates they are distinct conditions.
View Article and Find Full Text PDFManifestations of Hydralazine-Induced Vasculitis: A Case Series.
Cureus
October 2024
Internal Medicine, Northeast Georgia Medical Center Gainesville, Gainesville, USA.
Article Synopsis
- Hydralazine has been used for many years to treat high blood pressure, but it can cause serious side effects, including autoimmune diseases like ANCA-vasculitis and a lupus-like syndrome.
- The text discusses four cases of vasculitis linked to hydralazine, showing varying symptoms like lung hemorrhage, coughing up blood, and skin rashes.
- Diagnosing these conditions can be challenging, often requiring kidney biopsy, and the treatment involves stopping hydralazine and using immunosuppressants; caution is advised in using hydralazine over other blood pressure medications.
Antiphospholipid syndrome autoantibodies induction after treatment with anti-TNF alpha therapy in patients with IBD.
Gastroenterol Hepatol
September 2024
Crohn's and Colitis Attention Unit, Digestive System Service, Universitary Hospital Vall d'Hebron, Barcelona, Spain; Centro de Investigaciones Biomédicas en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
Introduction: Ant-iTNF treatment has been broadly linked with autoantibodies and autoimmune disorders development. After the clinical observation of aPTT (activated partial thromboplastin clotting time) prolongation in our cohort of IBD patients treated with anti-TNF, we sought to determine the presence of antiphospolipid antibodies in our population, along with antiphospholipid syndrome (APS) occurrence.
Methods: We included in the study 289 patients treated with anti-TNFα antibodies.
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