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Spatial chromosome organization and adaptation of the radiation-resistant extremophile Deinococcus radiodurans.
J Biol Chem
December 2024
Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
Article Synopsis
- Deinococcus radiodurans is a hardy microorganism known for its ability to survive extreme radiation and chemical damage, largely due to its advanced DNA repair skills.
- Researchers used chromosome conformation capture (3C) technology to analyze the 3D structure of its genome and how UV irradiation affects chromosome organization.
- The study found that UV exposure leads to reduced chromosome interactions and larger chromosomal domains, revealing insights into how a protein called DrEbfC regulates gene expression and helps the organism cope with environmental stresses.
CyAbrB2 is a nucleoid-associated protein in controlling hydrogenase expression during fermentation.
Elife
September 2024
School of Agriculture, Meiji University, Kawasaki, Japan.
The operon in sp. PCC 6803, encoding bidirectional hydrogenase responsible for H production, is transcriptionally upregulated under microoxic conditions. Although several regulators for transcription have been identified, their dynamics and higher-order DNA structure of region in microoxic conditions remain elusive.
View Article and Find Full Text PDFChromatin and gene regulation in archaea.
Mol Microbiol
August 2024
Division of Biosciences, RNAP Laboratory, Institute of Structural and Molecular Biology (ISMB), University College London, London, UK.
The chromatinisation of DNA by nucleoid-associated proteins (NAPs) in archaea 'formats' the genome structure in profound ways, revealing both striking differences and analogies to eukaryotic chromatin. However, the extent to which archaeal NAPs actively regulate gene expression remains poorly understood. The dawn of quantitative chromatin mapping techniques and first NAP-specific occupancy profiles in different archaea promise a more accurate view.
View Article and Find Full Text PDFTranscriptionally induced nucleoid-associated protein-like in combined-culture serves as a global effector of secondary metabolism.
Front Microbiol
July 2024
Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Combined-cultures involving mycolic acid-containing bacteria (MACB) can stimulate secondary metabolite (SM) production in actinomycetes. In a prior investigation, we screened JCM4020 mutants with diminished production of SMs, specifically undecylprodigiosin (RED), which was enhanced by introducing the MACB TP-B0596. In this study, we conducted mutational analysis that pinpointed the gene, which we assigned the gene name (combined-culture related regulatory protein no.
View Article and Find Full Text PDFIn Vitro Transcription Assay to Quantify Effects of H-NS Filaments on RNA Chain Elongation by RNA Polymerase.
Methods Mol Biol
July 2024
Departments of Biochemistry, University of Wisconsin - Madison, Madison, WI, USA.
Bacterial chromosomal DNA is structured and compacted by proteins known as bacterial chromatin proteins (i.e., nucleoid-associated proteins or NAPs).
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