This report documents the removal of a large mobile serpiginous right atrial thrombus using percutaneous intravascular techniques with fluoroscopic and transesophageal echocardiographic guidance. Technical aspects and potential complications are discussed.
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| http://dx.doi.org/10.1002/1522-726x(200012)51:4<479::aid-ccd23>3.0.co;2-f | DOI Listing |
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TAD-SIE: sample size estimation for clinical randomized controlled trials using a Trend-Adaptive Design with a Synthetic-Intervention-Based Estimator.
Trials
January 2025
Department of Electrical and Computer Engineering, Princeton University, Princeton, 08544, NJ, USA.
Background: Phase-3 clinical trials provide the highest level of evidence on drug safety and effectiveness needed for market approval by implementing large randomized controlled trials (RCTs). However, 30-40% of these trials fail mainly because such studies have inadequate sample sizes, stemming from the inability to obtain accurate initial estimates of average treatment effect parameters.
Methods: To remove this obstacle from the drug development cycle, we present a new algorithm called Trend-Adaptive Design with a Synthetic-Intervention-Based Estimator (TAD-SIE) that powers a parallel-group trial, a standard RCT design, by leveraging a state-of-the-art hypothesis testing strategy and a novel trend-adaptive design (TAD).
Confinement-induced Ni-based MOF formed on TiCT MXene support for enhanced capacitive deionization of chromium(VI).
Sci Rep
January 2025
School of Environmental Science and Engineering, Yancheng Institute of Technology, Yancheng, 224051, People's Republic of China.
MXenes, as a novel two-dimensional lamellar material, has attracted much attention. However, MXenes lamellar are prone to collapse and stacking under hydrogen bonding and interlayer van der Waals forces, which affects their electrochemical and capacitive deionization performance. A three-dimensional Ni-1,3,5-benzenetricarboxylate/TiCT (Ni-BTC/TiCT) composite electrode material was developed to enhance the electrochemical and capacitive deionization performance.
View Article and Find Full Text PDFC-terminal amides mark proteins for degradation via SCF-FBXO31.
Nature
January 2025
Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.
During normal cellular homeostasis, unfolded and mislocalized proteins are recognized and removed, preventing the build-up of toxic byproducts. When protein homeostasis is perturbed during ageing, neurodegeneration or cellular stress, proteins can accumulate several forms of chemical damage through reactive metabolites. Such modifications have been proposed to trigger the selective removal of chemically marked proteins; however, identifying modifications that are sufficient to induce protein degradation has remained challenging.
View Article and Find Full Text PDFInhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy.
Acta Pharmacol Sin
January 2025
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Spinal cord injury (SCI) is a serious trauma of the central nervous system (CNS). SCI induces a unique lipid-dense environment that results in the deposition of large amounts of lipid droplets (LDs). The presence of LDs has been shown to contribute to the progression of other diseases.
View Article and Find Full Text PDFA comparison of force adaptation in toddlers and adults during a drawer opening task.
Sci Rep
January 2025
Department of Psychology, Faculty of Psychology and Sport Science, Justus Liebig University, Otto-Behaghel-Str. 10F, 35394, Gießen, Germany.
Adapting movements to rapidly changing conditions is fundamental for interacting with our dynamic environment. This adaptability relies on internal models that predict and evaluate sensory outcomes to adjust motor commands. Even infants anticipate object properties for efficient grasping, suggesting the use of internal models.
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