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Pulmonary overlap syndrome in a patient with bronchial asthma.
BMJ Case Rep
January 2025
Pulmonary, Critical Care and Sleep Medicine, ESICPGIMSR, New Delhi, Delhi, India.
Allergic bronchopulmonary aspergillosis (ABPA) is a disease of immunocompetent patients, and invasive pulmonary aspergillosis is seen in immunocompromised patients. Hence, pulmonary overlap syndrome presenting with ABPA and invasive aspergillosis is extremely rare. We report a case of well-controlled bronchial asthma who presented with acute exacerbation and hypoxaemic respiratory failure.
View Article and Find Full Text PDFTracheobronchitis With Mediastinal Lymphadenopathy in a Patient With Well-Controlled HIV Infection.
Case Rep Infect Dis
November 2024
Clinical Research Center, Bumrungrad International Hospital, Bangkok, Thailand.
Article Synopsis
- Tracheobronchitis (AT) is a rare but severe form of invasive pulmonary aspergillosis that occurs infrequently in HIV-infected individuals, making up only 4.5% of cases according to recent studies.
- The use of modern antiretroviral therapy (ART) has decreased the incidence of opportunistic infections like AT in well-managed HIV patients.
- A case study of a young woman with controlled HIV who developed AT despite her treatment highlights the importance of recognizing respiratory symptoms, as swift diagnosis and antifungal treatment are crucial for better patient outcomes.*
Invasive Tracheobronchial Aspergillosis: A Fatal Complication in a Patient With Treated Mediastinal Lung Adenocarcinoma.
Cureus
September 2024
Department of Respiratory Medicine, Fukuoka University School of Medicine, Fukuoka, JPN.
Article Synopsis
- Invasive tracheobronchial aspergillosis (ITBA) is a serious fungal infection that affected a 75-year-old man with multiple health issues, including lung cancer and COPD.
- The patient experienced severe breathing difficulties, and while doctors initially thought his symptoms were due to cancer recurrence, a post-mortem revealed that ITBA was the actual cause.
- The case underscores the complexity of diagnosing ITBA, especially in patients with various risk factors, highlighting the need to consider fungal infections when diagnosing airway problems in high-risk individuals.
Fungal coinfection/superinfection in COVID-19 patients in a tertiary hospital in Mexico.
Biomedica
August 2024
Hospital Regional de Alta Especialidad Ixtapaluca, IMSS-BIENESTAR, Ciudad de México, México.
Introduction: Data on the prevalence of fungal coinfections/superinfections in patients with COVID-19 are limited.
Objective: To describe the prevalence of fungal coinfections/superinfections in patients with COVID-19, as well as risk factors and demographic, clinical, and microbiological characteristics.
Material And Methods: We included patients with a confirmed COVID-19 diagnosis and a confirmed fungal infection hospitalized in the ICU from March 2020 to December 2021.
Influenza-associated and COVID-19-associated pulmonary aspergillosis in critically ill patients.
Lancet Respir Med
September 2024
Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium; Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.
Influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA) are increasingly recognised as important complications in patients requiring intensive care for severe viral pneumonia. The diagnosis can typically be made in 10-20% of patients with severe influenza or COVID-19, but only when appropriate diagnostic tools are used. Bronchoalveolar lavage sampling for culture, galactomannan testing, and PCR forms the cornerstone of diagnosis, whereas visual examination of the tracheobronchial tract during bronchoscopy is required to detect invasive Aspergillus tracheobronchitis.
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