The incidence of post-sternotomy mediastinitis is 1 to 5% but the mortality is about 40%. The formation of a pseudo-aneurysm is a rare complication and an infectious origin is exceptionally rare. Diagnosis must be early because of the risk of rupture. In this case, a 47 year old patient developed slowly progressive mediastinitis presenting with a pseudo-aneurysm of the aorta. Surgery comprised a retrosternal transposition of the greater omentum.
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Crit Care
December 2024
Critical Care Department, Hospital Universitario Dr. Peset, Valencia, Spain.
Rapid multiplex molecular syndromic panels (RMMSP) (3 or more pathogens and time-to-results < 6 h) allow simultaneous detection of multiple pathogens and genotypic resistance markers. Their implementation has revolutionized the clinical landscape by significantly enhancing diagnostic accuracy and reducing time-to-results in different critical conditions. The current revision is a comprehensive but not systematic review of the literature.
View Article and Find Full Text PDFFront Physiol
November 2024
School of Industrial Management Engineering, Korea University, Seoul, Republic of Korea.
As delayed treatment of septic shock can lead to an irreversible health state, timely identification of septic shock holds immense value. While numerous approaches have been proposed to build early warning systems, these approaches primarily focus on predicting the future risk of septic shock, irrespective of its precise onset timing. Such early prediction systems without consideration of timeliness fall short in assisting clinicians in taking proactive measures.
View Article and Find Full Text PDFSci Rep
November 2024
Research Group of Intensive Care Medicine, Intensive Care Centre, Oulu University Hospital, University of Oulu and Medical Research Center (MRC), PO BOX 29, 90029, Oulu, Finland.
Background: Sepsis can lead to myocardial depression, playing a significant role in sepsis pathophysiology, clinical care, and outcome. To gain more insight into the pathophysiology of the myocardial response in sepsis, we investigated the expression of microRNA in myocardial autopsy specimens in critically ill deceased with sepsis and non-septic controls.
Materials And Methods: In this retrospective observational study, we obtained myocardial tissue samples collected during autopsy from adult patients deceased with sepsis (n = 15) for routine histological examination.
J Pediatr Orthop
November 2024
Division of Orthopaedics, The Children's Hospital of Philadelphia.
Front Immunol
November 2024
Servei de Medicina Intensiva, Hospital Universitari de Bellvitge, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain.
Introduction: Bacteremia is a life-threatening condition that can progress to sepsis and septic shock, leading to significant mortality in the emergency department (ED). The standard diagnostic method, blood culture, is time-consuming and prone to false positives and false negatives. Although not widely accepted, several clinical and artificial intelligence-based algorithms have been recently developed to predict bacteremia.
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