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Helicopter hoist operations in German mid-range mountains retrospective analysis of incidence, medical characteristics, and mission tactics.
Scand J Trauma Resusc Emerg Med
December 2024
German Air Rescue, DRF Stiftung Luftrettung Gemeinnützige AG, Rita-Maiburg-Str. 2, 70794, Filderstadt, Germany.
Article Synopsis
- Helicopter hoist operations (HHO) are crucial for conducting rescue missions in Germany's challenging mid-range mountain terrains, especially for outdoor sports-related injuries.
- A study analyzing HHO missions from 2020 to 2022 found 410 rescue cases, with 304 suitable for statistical analysis, revealing a peak in summer and on weekends with 75% of cases linked to trauma.
- The analysis indicated that many patients were in severe conditions requiring invasive treatments, and different air rescue bases employed varying tactics, affecting the efficiency of their missions.
A Computational Protocol for the Knowledge-Based Assessment and Capture of Pathologies.
Methods Mol Biol
November 2024
Center for Clinical Systems Biology, Rochester General Hospital, Rochester, NY, USA.
We propose that one of the main hurdles in delivering comprehensively informed care results from the challenges surrounding the extraction, representation, and retention of prior clinical experience and basic medical knowledge, as well as its translation into time- and context-informed actionable interventions. While emerging applications in artificial intelligence-based techniques, for example, large language models, offer impressive pattern association capabilities, they often fall short in producing human-readable explanations crucial to their integration into clinical care. Moreover, they require large well-defined and well-integrated data sets that typically conflict with the availability of such data in all but a few areas of medicine, for example, medical imaging and neuroimaging, noninvasive monitoring of bio-electrical activity, etc.
View Article and Find Full Text PDFA measles virus collective infectious unit that caused lethal human brain disease includes many locally restricted and few widespread copy-back defective genomes.
J Virol
November 2024
Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
During virus replication in cultured cells, copy-back defective viral genomes (cbDVGs) can arise. CbDVGs are powerful inducers of innate immune responses , but their occurrence and impact on natural infections of human hosts remain poorly defined. We asked whether cbDVGs were generated in the brain of a patient who succumbed to subacute sclerosing panencephalitis (SSPE) about 20 years after acute measles virus (MeV) infection.
View Article and Find Full Text PDFMaking sense together: dance improvisation as a framework for a collaborative interdisciplinary learning processes.
BMC Neurosci
October 2024
Structures Formelles du Langage, UMR 7023, CNRS, Paris, France.
This editorial outlines the outcome of an interdisciplinary session on collective sense-making through dance improvisation, which took place during the 'Neural and Social Bases of Creative Movement' workshop. We argue that joint improvisation practices place the scientist in a privileged position to reveal the nature of cognitive and creative behaviors.
View Article and Find Full Text PDFInsight into RecA-mediated repair of double strand breaks is provided by probing how contiguous heterology affects recombination.
J Biol Chem
November 2024
Department of Physics, Harvard University, Cambridge, Massachusetts, USA. Electronic address:
Homologous recombination can promote correct repair of double strand breaks in DNA by aligning a sequence region in the broken chromosome with the corresponding sequence region in an unbroken chromosome. D-loops join the broken and unbroken chromosomes during homology testing. Previous work studied how some mismatches affect the stability of D-loops, but they did not probe whether the D-loops disrupt regions of contiguous mismatches or simply bypass them.
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