To investigate combinations of antibiotics against Pseudomonas aeruginosa, the in vitro effects of combinations of meropenem with each of three aminoglycosides, arbekacin, amikacin and netilmicin, were evaluated using an agar dilution chequerboard technique. The combinations of meropenem and aminoglycosides were effective against almost all P. aeruginosa strains tested, which included meropenem-resistant strains. Increased synergic effects were observed in combinations that included arbekacin or amikacin. None of the combinations had an antagonistic effect. Most of the synergic and additive effects were achieved at clinically relevant concentrations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jac/46.6.901 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recurrent relapsing remitting Serratia marcescens infective endocarditis in a former drug-using patient.
Diagn Microbiol Infect Dis
January 2025
Department of Radiology, Bichat Hospital, Assistance Publique-Hôpitaux de Paris, 46 rue Henri Huchard, 75018 Paris, France; INSERM U1148, Paris, France; Paris University, Paris, France. Electronic address:
Unusual course of Serratia marcescens (SM) infectious endocarditis (IE) and literature review (2016-2024; 26 cases). A 44-year-old man, with chronic venous ulcers, presented 21/2 years after a MSSA tricuspid valve IE, a tricuspid and aortic valves SM IE . After 6 weeks of antibiotherapy (meropenem i.
View Article and Find Full Text PDFAntibiotic Resistance as a Functional Characteristic of Urban Dust Particles' Microbial Communities.
Biology (Basel)
December 2024
Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", 142290 Pushchino, Russia.
Urban dust samples were collected in Moscow (Russia) in June 2021. The samples were collected in three functional zones of Moscow (traffic, residential, and recreational) and included air microparticles, leaf dust, and paved dust. Data on the taxonomic composition of bacterial communities were obtained for dust samples, and their functional characteristics were predicted using PICRUSt2 2.
View Article and Find Full Text PDFIntroduction Urinary tract infections (UTIs) are one of the most common bacterial infections encountered in community and healthcare settings. Increasing antimicrobial resistance patterns worldwide have limited the treatment options available. Overuse of carbapenems which were considered as the last resort for multi-drug resistant UTIs over the past decade has led to the emergence of carbapenem-resistant Enterobacterales (CRE).
View Article and Find Full Text PDFResponse Surface D-Optimal Design for Optimizing Fortimicins Production by Micromonospora olivasterospora and New Synergistic Fortimicin-A-Antibiotic Combinations.
Curr Microbiol
January 2025
Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Fortimicins (FTMs) are fortamine-containing aminoglycoside antibiotics (AGAs) produced by M. olivasterospora DSM 43868 with excellent bactericidal activities against a wide range of Enterobacteriaceae and synergistic activity against multidrug-resistant (MDR) pathogens. Fortimicin-A (FTM-A), the most active member of FTMs, has the lowest susceptibility to inactivation by the aminoglycoside modifying enzymes (AMEs).
View Article and Find Full Text PDFDistribution and antibiotic resistance patterns of across different point sources of pollution in the Buriganga River, Bangladesh.
J Water Health
December 2024
Department of Genetic Engineering and Biotechnology, Jagannath University, Dhaka 1100, Bangladesh.
is a pathogenic bacterium widely distributed in the environment, with increasing concerns about multidrug-resistant (MDR) strains in riverine systems. In this study, we assessed the antibiotic resistance of 50 isolates from surface water samples collected at seven distinct sites along the Buriganga River. Antibiotic sensitivity was tested using the Kirby-Bauer Disk Diffusion method.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!