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Extrahepatic Manifestations of Chronic Hepatitis C Virus (HCV) Infection.
Cureus
March 2024
Rheumatology, Centinela Hospital, Los Angeles, USA.
Article Synopsis
- Hepatitis C virus (HCV) is a significant cause of serious liver diseases, such as chronic hepatitis and liver cirrhosis, as well as hepatocellular carcinoma.
- Chronic HCV infection is also linked to various extrahepatic conditions that can result in serious health issues, including cryoglobulinemia, autoimmune diseases, and cardiovascular problems.
- Understanding these extrahepatic manifestations is crucial for early diagnosis and effective anti-viral treatment, which can help reduce long-term complications related to chronic HCV infection.
The article presents a description of a patient with chronic HCV infection and multiple extrahepatic manifestations, which manifested in dynamics and were recorded with a different sequence during 15 years of follow-up. In the patient we observed, the most frequently recorded extrahepatic manifestations were verified: porphyria cutanea tarda, mixed cryoglobulenemia, and utoimmune thyroiditis. Chronic HCV infection is often diagnosed in the presence of psoriasis was assessed as a paraneoplastic disease.
View Article and Find Full Text PDFEpidermolysis bullosa acquisita.
An Bras Dermatol
July 2022
Department of Dermatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Epidermolysis bullosa acquisita is a rare autoimmune disease, characterized by the synthesis of anti-collagen VII autoantibodies, the main component of hemidesmosome anchoring fibrils. The antigen-antibody binding elicits a complex inflammatory response, which culminates in the loss of dermo-epidermal adhesion of the skin and/or mucous membranes. Skin fragility with bullae, erosions, and milia in areas of trauma characterizes the mechanobullous form of the disease.
View Article and Find Full Text PDFSystemic lupus erythematosus and hydroxychloroquine-related acute intermittent porphyria.
Rheumatol Int
May 2020
Department of Medicine, Universitat Autonòma, Catalonia, Barcelona, Spain.
Porphyrias, particularly acute intermittent porphyria (AIP), are rare disorders which could be associated with systemic lupus erythematosus (SLE). Although the association with AIP has been known since 1952, only 11 cases have been published to date. It is widely known that precipitating causes such as infections, hormonal changes, sunlight exposure, stress and drugs could provoke an AIP crisis.
View Article and Find Full Text PDFCutaneous Manifestations of Scleroderma and Scleroderma-Like Disorders: a Comprehensive Review.
Clin Rev Allergy Immunol
December 2017
Section of Dermatology, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse cutaneous systemic sclerosis with divergent patterns of organ involvement, autoantibody profiles, management, and prognostic implications. Although systemic sclerosis is considered the disease prototype that causes cutaneous sclerosis, there are many other conditions that can mimic and be confused with SSc. They can be classified into immune-mediated/inflammatory, immune-mediated/inflammatory with abnormal deposit (mucinoses), genetic, drug-induced and toxic, metabolic, panniculitis/vascular, and (para)neoplastic disorders according to clinico-pathological and pathogenetic correlations.
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