AI Article Synopsis
Article Abstract
WSL-1/TRAMP (DR3) is a member of the tumour necrosis factor (TNF) receptor superfamily which exhibits effects on NF-kappaB activation and apoptosis. TWEAK, a novel TNF-related molecule, has been proposed as the ligand for this receptor. Utilising both human and murine TWEAK ligand, it is shown that TWEAK and WSL-1/TRAMP do not interact in an in vitro binding assay and that TWEAK binds strongly to cells that do not express WSL-1/TRAMP on the cell surface. Biological activity of TWEAK is also observed in these cells. Finally, cells isolated from WSL-1/TRAMP knockout mice are shown to retain their ability to interact with TWEAK. These results suggest that WSL-1/TRAMP is not the major receptor for TWEAK
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0014-5793(00)02219-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Construing the resilience to osmotic stress using endophytic fungus in maize (Zea mays L.).
Plant Mol Biol
January 2025
Department of Plant Pathology, University of Agricultural Sciences, Gandhi Krishi Vignana Kendra (GKVK), Bengaluru, India.
In a wake of shifting climatic scenarios, plants are frequently forced to undergo a spectrum of abiotic and biotic stresses at various stages of growth, many of which have a detrimental effect on production and survival. Naturally, microbial consortia partner up to boost plant growth and constitute a diversified ecosystem against abiotic stresses. Despite this, little is known pertaining to the interplay between endophytic microbes which release phytohormones and stimulate plant development in stressed environments.
View Article and Find Full Text PDFAssociation between circulating inflammatory proteins and temporomandibular disorders: insight from a two-sample Mendelian randomization analysis.
J Appl Oral Sci
January 2025
Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Ninth People's Hospital, Department of Orthodontics, Shanghai, China.
Background: Past studies have indicated links between specific inflammatory proteins in the bloodstream and temporomandibular disorders (TMDs). Nonetheless, there remains the need for further solid research pinpointing the exact causes behind these associations. This Mendelian randomization (MR) study aims to examine the association between 91 circulating inflammatory proteins and TMDs.
View Article and Find Full Text PDFRapid microfluidic perfusion system enables controlling dynamics of intracellular pH regulated by Na/H exchanger NHE1.
Lab Chip
January 2025
CNRS UMR 7010, Institut de Physique de Nice (INPHYNI), Université Côte d'Azur, 06108 Nice, France.
pH regulation of eukaryotic cells is of crucial importance and influences different mechanisms including chemical kinetics, buffer effects, metabolic activity, membrane transport and cell shape parameters. In this study, we develop a microfluidic system to rapidly and precisely control a continuous flow of ionic chemical species to acutely challenge the intracellular pH regulation mechanisms and confront predictive models. We monitor the intracellular pH dynamics in real-time using pH-sensitive fluorescence imaging and establish a robust mathematical tool to translate the fluorescence signals to pH values.
View Article and Find Full Text PDFAssociations of nutritional intake and inflammatory factors with sarcopenia in community-dwelling older adults: a cross-sectional study.
Eur Geriatr Med
January 2025
Department of Public Health, Jining Medical University, Jining, 272000, China.
Purpose: Sarcopenia is an age-related disease that is related to nutritional intake and chronic low-grade inflammation. The aim of this study was to investigate the association of dietary intake, inflammatory markers and sarcopenia among the community-dwelling older adults.
Methods: A total of 1001 older adults aged 60 and above were recruited.
Evaluation of the effect of therapeutic plasma exchange on serum cytokine levels in pediatric intensive care unit.
Ther Apher Dial
January 2025
Department of Pediatric Rheumatology, Health Science University, Umraniye Research and Training Hospital, Istanbul, Turkey.
Introduction: Therapeutic plasma exchange (TPE) is crucial for saving lives when used appropriately. This study aimed to assess TPE's impact on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) protein and IL-6 levels in critically ill pediatric patients.
Methods: Conducted between May 2022 and December 2022, the study observed pediatric intensive care unit (PICU) patients undergoing TPE, recording demographics, lab results, TWEAK, and IL-6 levels pre- and post-procedure.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!