This study was aimed at investigating the effects of lamotrigine (LTG) on electrically evoked field excitatory postsynaptic potentials (fEPSP) and population spikes in the CA1 hippocampal region of guinea pigs. The concentration response curves showed different actions of LTG on fEPSP and on population spikes. The data are in contrast to previous findings that suggest the drug acts primarily on presynaptic sites via a blockade of the release of excitatory amino acids. In the range of therapeutic plasma levels, synaptic transmission was not affected.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000054848 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
β-adrenergic receptor-induced E-S potentiation in the dorsal and ventral hippocampus.
Front Synaptic Neurosci
December 2024
Laboratory of Physiology, Department of Medicine, University of Patras, Patras, Greece.
β-adrenergic receptors (β-ARs) play a critical role in modulating learning, memory, emotionality, and long-term synaptic plasticity. Recent studies indicate that β-ARs are necessary for long-term potentiation (LTP) induction in the ventral hippocampus under moderate synaptic activation conditions that do not typically induce LTP. To explore potential dorsoventral differences in β-AR-mediated effects, we applied the β-AR agonist isoproterenol (10 μM, 30 min) to dorsal and ventral hippocampal slices, recording field excitatory postsynaptic potentials (fEPSPs) and population spikes (PSs) from the CA1 region.
View Article and Find Full Text PDFField EPSPs of Dentate Gyrus Granule Cells Studied by Selective Optogenetic Activation of Hilar Mossy Cells in Hippocampal Slices.
Hippocampus
January 2025
Departments of Child & Adolescent Psychiatry, Neuroscience & Physiology, and Psychiatry, and the Neuroscience Institute, New York University Langone Health, New York, New York, USA.
Article Synopsis
- Researchers explored how glutamatergic mossy cells (MCs) in the dentate gyrus (DG) connect to granule cells (GCs), using optogenetics to activate MC axons specifically.
- They found that this optogenetic stimulation could elicit field excitatory postsynaptic potentials (fEPSPs) in GCs in the inner molecular layer (IML), which were consistent across the DG.
- The fEPSPs recorded were relatively weak, showing low amplitude and minimal population spikes, indicating that the MC input to GCs is generally weak but widespread throughout the granule cell population.
Genetic machinery which accompanies metaplasticity operates differentially in experimental model of autism.
Int J Dev Neurosci
February 2025
Physiology Department of Medical School, University of Erciyes, Kayseri, Turkey.
Article Synopsis
- * Researchers treated Wistar dams with VPA to investigate behavioral and neurological changes in their male offspring, which exhibited impairments in social interaction, sensorimotor coordination, and synaptic activity measured by fEPSP.
- * Findings indicated that while the overall metaplastic response was similar between VPA-treated and control animals, key autism-related gene expressions were significantly reduced in the offspring of VPA-treated rats, suggesting a potential adaptation mechanism in response to disrupted gene expression.
Unlabelled: Glutamatergic dentate gyrus (DG) mossy cells (MCs) innervate the primary DG cell type, granule cells (GCs). Numerous MC synapses are on GC proximal dendrites in the inner molecular layer (IML). However, field recordings of the GC excitatory postsynaptic potential (fEPSPs) have not been used to study this pathway selectively.
View Article and Find Full Text PDFArcKR expression modifies synaptic plasticity following epileptic activity: Differential effects with in vitro and in vivo seizure-induction protocols.
Epilepsia
July 2024
School of Life Sciences, University of Warwick, Coventry, UK.
Objectives: Pathological forms of neural activity, such as epileptic seizures, modify the expression pattern of multiple proteins, leading to persistent changes in brain function. One such protein is activity-regulated cytoskeleton-associated protein (Arc), which is critically involved in protein-synthesis-dependent synaptic plasticity underlying learning and memory. In the present study, we have investigated how the expression of ArcKR, a form of Arc in which the ubiquitination sites have been mutated, resulting in slowed Arc degradation, modifies group I metabotropic glutamate receptor-mediated long-term depression (G1-mGluR-LTD) following seizures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!