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Novel Quinoline- and Naphthalene-Incorporated Hydrazineylidene-Propenamide Analogues as Antidiabetic Agents: Design, Synthesis, and Computational Studies.
Pharmaceuticals (Basel)
December 2024
Department of Chemistry, Faculty of Science, Taibah University, Madinah 42353, Saudi Arabia.
Type 2 diabetes has become a significant global health challenge. Numerous drugs have been developed to treat the condition, either as standalone therapies or in combination when glycemic control cannot be achieved with a single medication. As existing treatments often come with limitations, there is an increasing focus on creating novel therapeutic agents that offer greater efficacy and fewer side effects to better address this widespread issue.
View Article and Find Full Text PDFA Novel In Vivo Method Using to Evaluate α-Glucosidase Inhibition by Natural Products for Type 2 Diabetes Treatment.
Pharmaceuticals (Basel)
December 2024
Department of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
Background: Non-insulin-dependent diabetes mellitus, or type 2 diabetes, is one of the diseases of greatest concern worldwide, and research into natural compounds that are capable of regulating glycemia and insulin resistance is therefore gaining importance. In the preclinical stages, is considered a promising in vivo model for research into this disease. Most studies have been carried out using mutant strains and observing changes in their phenotype rather than directly measuring the effects within the worms.
View Article and Find Full Text PDFStructural Characterization and In Vitro and In Silico Studies on the Anti--Glucosidase Activity of Anacardic Acids from .
Foods
December 2024
Embrapa Alimentos e Territórios, Maceió 57020-050, AL, Brazil.
The growing focus on sustainable use of natural resources has brought attention to cashew nut shell liquid (CNSL), a by-product rich in anacardic acids (AAs) with potential applications in diabetes treatment. In this study, three different AAs from CNSL, monoene (15:1, AAn1), diene (15:2, AAn2), and triene (15:3, AAn3), and a mixture of the three (mix) were evaluated as -glucosidase inhibitors. The samples were characterized by combining 1D and 2D NMR spectroscopy, along with ESI-MS.
View Article and Find Full Text PDFGrape Pomace as a Source of Phenolics for the Inhibition of Starch Digestion Enzymes: A Comparative Study and Standardization of the Efficacy.
Foods
December 2024
Department of Food, Environmental and Nutritional Sciences, University of Milan, 20133 Milano, Italy.
The increase in the incidence of hyperglycemia and diabetes poses the challenge of finding cost-effective natural inhibitors of starch digestion enzymes. Among natural compounds, phenolics have been considered as promising candidates. The aims of this study were as follows: (a) to investigate the effectiveness of the inhibition of different winemaking byproducts towards intestinal brush border α-glucosidase and pancreatic α-amylase in vitro; (b) to calculate an efficacy index relative to the standard acarbose for the phenolic pool of winemaking byproducts, as well as for isolated phenolic compounds and for the phenolic pools of different plants studied in the literature, in order to rank winemaking byproducts with respect to the reference drug and other natural alternatives.
View Article and Find Full Text PDFDrying: A Practical Technology for Blueberries ( L.)-Processes and their Effects on Selected Health-Promoting Properties.
Antioxidants (Basel)
December 2024
Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Camino La Pirámide 5750, Santiago 8580745, Chile.
The global dried blueberry market is steadily growing, driven by the creation of innovative blueberry-based products. This trend presents an opportunity to explore a previously untapped segment of the blueberry market in Chile. In this study, a comprehensive assessment of four drying techniques (hot-air drying [HAD], vacuum drying [VD], infrared drying [IRD], and freeze-drying [FD]) was conducted to determine best operating conditions and preserve the health-promoting properties of blueberries.
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