AI Article Synopsis
- Breast cancer is primarily an estrogen-dependent tumor, with around 30% of cases treatable by estrogen-blocking agents, but many tumors develop resistance to such therapies.
- Recent research has illuminated the molecular mechanisms behind this resistance, highlighting the interplay between estrogen signaling and other growth factor pathways at the receptor level.
- Advances in understanding these processes, along with the potential development of a pure antiestrogen, pave the way for more advanced hormone therapies in breast cancer treatment.
Article Abstract
Breast Cancer is thought to develope as an estrogen-dependent tumor. Approximately 30% of breast cancers can be treated by agents that block estrogen. However, all breast cancers have been known to acquire the hormone therapy-resistant phenotype with ultimate fatal results. Recent progress in breast cancer research has porvided the important clues for elucidating the molecular mechanism of this conversion. The presence of the cross-talk between estrogen signaling and other mitogen-dependent signaling has been clarified at the estrogen recepter level. In addition, an estrogen-dependent transcriptional control mechanism has been characterized in detail. These breakthrough and the development of a pure antiestrogen would make it possible to consider the more sophisticated hormone therapy. In this review article, I summarized the current findings which seem to be essential in the treatment of breast cancer.
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| http://dx.doi.org/10.1007/BF02967412 | DOI Listing |
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