AI Article Synopsis
- A new des-fluoro(6) quinolone called BMS-284756 was found to be highly effective against a variety of bacteria, including both methicillin-resistant staphylococci and penicillin-resistant pneumococci.
- It showed strong inhibition rates against Enterococcus faecium (including vancomycin-resistant strains) and achieved impressive results against Enterobacteriaceae and gastroenteric pathogens.
- BMS-284756 also performed well against nonfermenters, anaerobic bacteria, and challenging microbial species, suggesting its potential for treating various infections in clinical settings.
Article Abstract
The in vitro spectrum of a novel des-fluoro(6) quinolone, BMS-284756, was compared with those of five fluoroquinolones (trovafloxacin, moxifloxacin, levofloxacin, ofloxacin, and ciprofloxacin). BMS-284756 was among the most active and often was the most active quinolone against staphylococci (including methicillin-resistant strains), streptococci, pneumococci (including ciprofloxacin-nonsusceptible and penicillin-resistant strains), and Enterococcus faecalis. BMS-284756 inhibited approximately 60 to approximately 70% of the Enterococcus faecium (including vancomycin-resistant) strains and 90 to 100% of the Enterobacteriaceae strains and gastroenteric bacillary pathogens at the anticipated MIC susceptible breakpoint (
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC90204 | PMC |
| http://dx.doi.org/10.1128/AAC.44.12.3351-3356.2000 | DOI Listing |
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