Profound knowledge of the different activities and side effects of the various types and combinations of HRT regimens is of paramount importance for counseling peri- and postmenopausal women. In this article some practical aspects of different topics concerning HRT such as influence of HRT on blood sugar, diabetes, blood pressure, hypertension, serum lipids, migraine, and progestin intolerance are discussed.
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http://dx.doi.org/10.1024/0040-5930.57.10.643 | DOI Listing |
JAMA Psychiatry
March 2025
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Importance: Expectancy effects are significant confounding factors in psychiatric randomized clinical trials (RCTs), potentially affecting the interpretation of study results. This narrative review is the first, to our knowledge, to explore the relationship between expectancy effects, compromised blinding integrity, and the effects of active treatment/placebo in psychiatric RCTs. Additionally, we present statistical and experimental approaches that may help mitigate the confounding impact of expectancy effects.
View Article and Find Full Text PDFJAMA Netw Open
March 2025
Exercise Medicine Research Institute, Edith Cowan University, Perth, Australia.
Importance: Sexual dysfunction is a common adverse effect of prostate cancer treatment, and current management strategies do not adequately address physical and psychological causes. Exercise is a potential therapy in the management of sexual dysfunction.
Objective: To investigate the effects of supervised, clinic-based, resistance and aerobic exercise with and without a brief psychosexual education and self-management intervention (PESM) on sexual function in men with prostate cancer compared with usual care.
Int J Radiat Oncol Biol Phys
March 2025
GenesisCare, Radiation Department, Madrid, Spain.
Purpose: The FAST-Forward study paved the way for ultrahypofractionation (UHF) in breast cancer. We prospectively registered and analyzed our case series receiving UHF + simultaneous integrated boost (SIB) to further reduce the treatment to a total of 5 days. The study aimed to present the 6-month early side effects results of the first patients treated with this scheme in 16 radiation oncology centers in Spain.
View Article and Find Full Text PDFAging Dis
February 2025
Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Nanozymes, which are nanomaterials that replicate the catalytic activities of natural enzymes in biological systems, have recently demonstrated considerable potential in improving cancer immunotherapy by altering the tumor microenvironment. Nanozyme-driven immune responses represent an innovative therapeutic modality with high effectiveness and minimal side effects. These nanozymes activate the immune system to specifically recognize and destroy cancer cells.
View Article and Find Full Text PDFLatinx sexual minority men (SMM) living in the U.S. endure intersectional oppression which has been linked to their engagement in sexual risk behaviors, increasing their risk for adverse outcomes such as HIV/STI/STD contraction and ongoing poverty.
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