Purpose: In fluorescein angiography (FAG), glaucomatous eyes show a zone of no fluorescence around the disc and hyperfluorescence indicating serum diffusion at the margin of the zone, which play some role in glaucomatous optic nerve damage. But detailed FAG findings have not been reported in non-glaucomatous eyes. We conducted a study to investigate whether peripapillary FAG findings in glaucomatous eyes were specific to glaucoma or not.
Materials And Methods: 46 eyes of 46 subjects were selected by some reservations from all the non-glaucomatous patients undergoing FAG in 1996. We studied FAG films and measured the zone of no fluorescence adjacent to the disc (non-fluorescent zone).
Result: 44 eyes (95.6%) showed a non-fluorescent zone. The non-fluorescent zone was clearly wider in temporal sectors than nasal sectors, and its width was related to the refraction. There were two types of non-fluorescent zone, one showing hyperfluorescence from the outer boundary of the zone in the late phase, and the other showing hyperfluorescence from the disc margin. The width of the non-fluorescent zone in the former type was wider than in the latter type. These results are similar to the findings in glaucomatous eyes.
Conclusion: These findings suggest that not only glaucomatous eyes but also non-glaucomatous eyes have a variety of histological structures and serum diffusion around the disc.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Microfluidic sensor using pH gradient with hybrid magnetoliposomes containing laccase immobilized nanocrystals.
Mikrochim Acta
November 2024
Departamento de Química Analítica, Instituto Universitario de Investigación en Química Fina y Nanoquímica (IUNAN), Universidad de Córdoba, Campus de Rabanales, Edificio Anexo "Marie Curie", 14071, Córdoba, Spain.
A method using pH gradient to modify the phospholipid dissociation has been developed using hybrid magnetoliposomes with encapsulated enzyme laccase, which has been immobilized on hydrophilic magnetic nanocrystals (PAA-MNCs) retained in the reaction/detection zone of a microfluidic system. The hybrid magnetoliposomes act as micro containers, providing the safe transfer of the enzyme to the reaction/detection site, where it is retained, and preconcentration of the enzyme in this place occurs, which improves the system's sensitivity. The use of pH change involves the lack of external molecules to release the encapsulated materials.
View Article and Find Full Text PDFMolecular imprinting-based indirect fluorescence detection strategy implemented on paper chip for non-fluorescent microcystin.
Nat Commun
October 2023
CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, 264003, Yantai, China.
Fluorescence analysis is a fast and sensitive method, and has great potential application in trace detection of environmental toxins. However, many important environmental toxins are non-fluorescent substances, and it is still a challenge to construct a fluorescence detection method for non-fluorescent substances. Here, by means of charge transfer effect and smart molecular imprinting technology, we report a sensitive indirect fluorescent sensing mechanism (IFSM) and microcystin (MC-RR) is selected as a model target.
View Article and Find Full Text PDFBoth incompatible and compatible rhizobia inhabit the intercellular spaces of leguminous root nodules.
Plant Signal Behav
December 2023
Division of Arts and Sciences, International Christian University, Mitaka, Japan.
In addition to rhizobia, many types of co-existent bacteria are found in leguminous root nodules, but their habitats are unclear. To investigate this phenomenon, we labeled USDA122 and sp. SSBR45 with sp.
View Article and Find Full Text PDFAdvanced glycation end-product accumulation differs by location and sex in aged osteoarthritic human menisci.
Osteoarthritis Cartilage
March 2023
Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States; Department of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, VA, United States. Electronic address:
Objective: There is a clear link between increasing age and meniscus degeneration, leading to increased injury, osteoarthritis (OA) progression, and often total knee replacement. Advanced glycation end-products (AGEs) are non-enzymatic crosslinks and adducts that accumulate in collagen with age, altering tissue mechanics and cell function, ultimately leading to increased injury and inflammation. AGEs, both fluorescent and non-fluorescent, play a central role in age-related degradation of tissues throughout the body; however, little is known about their role in meniscus degeneration.
View Article and Find Full Text PDFMicroplastic pollution in show cave sediments: First evidence and detection technique.
Environ Pollut
January 2022
Department of Environment, Land and Infrastructure Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Torino, Italy. Electronic address:
Microplastic particles are a global problem, which has been widely found in marine and terrestrial environments. However, microplastic pollution in caves and karst aquifers is still poorly studied. To improve the current knowledge of microplastic pollution, we investigated the sediments of a show cave in Italy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!