AI Article Synopsis
- The study examines the roles of cathepsin D and nm23 in laryngeal carcinomas, focusing on their expressions and effects on tumor invasion and metastasis.
- Nearly all laryngeal carcinomas expressed nm23 protein, while only 43% showed cathepsin D positivity, with no significant differences noted between metastatic and non-metastatic cases.
- The findings suggest that both nm23 and cathepsin D do not impact tumor progression in laryngeal carcinomas.
Article Abstract
Aims: Cathepsin D and nm23 are two of the factors, investigated recently that have effects on invasion and metastasis of malign tumors. Cathepsin D is an aspartyl protease that plays a role in the invasion of tumor cells and is also found in stromal macrophages which are said to play a role in tumor invasiveness. The nm23 gene encodes nucleoside diphosphate (NDP) kinase that has a metastatic suppressor effect in some tumors but not in others. The aim of this study is to investigate expressions of nm23 and cathepsin D in laryngeal carcinomas.
Methods: Immunohistochemical method was used in 28 laryngeal carcinomas to demonstrate the expression of nm23 and cathepsin-D.
Main Results: Nearly all (26 of 28, 96 % ) carcinomas expressed nm23 protein without any difference between metastatic and non-metastatic carcinomas. 12 of 28 carcinomas (43 %) showed cathepsin D positivity regardless of T stage of the tumors.
Conclusion: We found that nm23 expression and cathepsin D positivity had no effect on tumor progression in laryngeal carcinomas.
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