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Adherence to ESMO guidelines on cancer pain management and their applicability to specialist palliative care centers: An observational, prospective, and multicenter study.
Pain Pract
October 2024
Pain and Palliative Care Research Unit, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Introduction: Pain management in late-stage cancer patients is a complex clinical problem. The historical guidelines were from the World Health Organization (WHO). Recently, ESMO produced guidelines consistent with 52 recommendations applicable to the entire period of disease since the pain appears.
View Article and Find Full Text PDFStudy of risk factors and clinical management of patients with clinical non-response due to low plasma levels of anti-tubercular drugs.
Monaldi Arch Chest Dis
July 2024
Department of Tuberculosis and Chest Diseases, National Institute of Tuberculosis and Respiratory Diseases, New Delhi.
Article Synopsis
- This study evaluated therapeutic drug monitoring of key anti-tubercular medications, rifampicin and isoniazid, among 75 patients with drug-sensitive tuberculosis who were not responding to standard treatment.
- An intervention was applied to patients with low drug levels, either by increasing dosages or adding second-line drugs to their regimen.
- Results showed that 85.5% of patients had low drug levels, and those who received additional treatment had a favorable outcome in 59.6% of cases, suggesting that addressing low drug levels can improve treatment efficacy.
Minimally invasive elective gastrectomy after preoperative chemotherapy in a patient with frailty who presented with locally far advanced-stage gastric cancer: a case report.
Surg Case Rep
June 2024
Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, 7-5-2, Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.
Article Synopsis
- A case of advanced gastric antrum cancer in an 80-year-old male patient was successfully treated with laparoscopic distal gastrectomy after initial preoperative chemotherapy, despite the cancer having spread to multiple organs.
- The patient, who had a poor general condition (performance status score of 3), underwent three cycles of chemotherapy, improving his health to a score of 1 and achieving a partial response.
- Post-surgery, histopathological analysis showed no signs of remaining cancer, indicating a complete cure.
Stapedotomy Versus Cochlear Implantation for Far Advanced Otosclerosis: Insights From a Patient With Matched Preoperative and Postoperative Function.
Otol Neurotol
June 2024
Department of Otolaryngology-Head and Neck Surgery.
Objective: To examine patient preference after stapedotomy versus cochlear implantation in a unique case of a patient with symmetrical profound mixed hearing loss and similar postoperative speech perception improvement.
Patients: An adult patient with bilateral symmetrical far advanced otosclerosis, with profound mixed hearing loss.
Intervention: Stapedotomy in the left ear, cochlear implantation in the right ear.
Far-advanced gastric cancer has always been a challenging problem in clinical treatment and a key direction for breakthrough research. Non-surgical treatments are primarily managed in patients with far-advanced gastric cancer. However, with the advancement of therapeutic methods in recent years, tumor foci can be significantly regressed after effective preoperative treatment, in prospect ofregaining the opportunity of radical gastrectomy.
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