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Evaluation of long-acting cabotegravir safety and pharmacokinetics in pregnant women in eastern and southern Africa: a secondary analysis of HPTN 084.
J Int AIDS Soc
January 2025
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Introduction: Long-acting injectable cabotegravir (CAB-LA) for pre-exposure prophylaxis significantly reduced HIV acquisition in HPTN 084. We report on the safety and CAB-LA pharmacokinetics in pregnant women during the blinded period of HPTN 084.
Methods: Participants were randomized 1:1 to either active cabotegravir (CAB) plus tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) placebo or active TDF/FTC plus CAB placebo.
Assessment of adverse pregnancy outcomes associated with Helicobacter pylori infection.
Sci Rep
December 2024
Department of Gynecology and Obstetrics, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Sect. 4 , Taichung, 40705, Taiwan.
The background of Helicobacter pylori (H. pylori) infection is complex, and its influence on adverse pregnancy outcomes is inconsistently reported. We performed a multi-institutional, retrospective analysis using de-identified electronic health records from the TriNetX Research Network to compare various pregnancy outcomes in women with and those without H.
View Article and Find Full Text PDFSex-specific associations between maternal exposure to metal mixtures and fetal growth trajectories: A prospective birth cohort study.
Sci Total Environ
December 2024
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China; MOE Key Laboratory of Population Health Across Life Cycle, 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address:
Article Synopsis
- The study investigates how prenatal exposure to metal mixtures affects fetal growth, focusing on differences between male and female fetuses.
- Researchers analyzed data from 1,041 pregnant women, measuring 12 metals in maternal blood at various stages of pregnancy and assessing fetal growth through a specific indicator called biparietal diameter (BPD).
- Findings reveal that cobalt has opposing effects on growth trajectories by sex; it negatively impacts male fetuses while positively affecting females, with significant interactions between metal exposure and sex influencing growth outcomes.
Antibiofilm Activity of Epinecidin-1 and Its Variants Against Drug-Resistant and Isolates from Vaginal Candidiasis Patients.
Infect Dis Rep
December 2024
Microbial Biotechnology Laboratory, Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli 620024, India.
Indwelling intrauterine contraceptive devices (IUDs) have surfaces that facilitate the attachment of spp., creating a suitable environment for biofilm formation. Due to this, vulvovaginal candidiasis (VVC) is frequently linked to IUD usage, necessitating the prompt removal of these devices for effective treatment.
View Article and Find Full Text PDFImpact of schistosomiasis infection on maternal and neonatal outcomes in pregnancy: a prospective cohort study in Nigeria.
BMC Pregnancy Childbirth
December 2024
Department of Obstetrics & Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra state, P.M.B 5025, Nnewi, West Africa, Nigeria.
Background: Schistosomiasis, a neglected tropical disease, affects approximately 40 million women of reproductive age contributing to preventable anaemia during pregnancy, intrauterine growth retardation and low birth weight. In spite of the high prevalence rate of this disease among school aged children in Abakaliki, no study in Abakaliki has looked at the burden of Schistosomal infection in pregnancy with a view to determining maternal and neonatal outcomes.
Objective: To determine the association between schistosomal infection and maternal anemia, low birth weight, and other neonatal outcomes in Abakaliki.
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