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Bullous Pyoderma Gangrenosum Associated with Antiphospholipid Syndrome: A Case Report and Literature Review.
Oman Med J
July 2024
Family Medicine General Foundation Program, Oman Medical Specialty Board, Muscat, Oman.
We report a rare case of a middle-aged Omani woman who was known to have primary antiphospholipid syndrome, glucose-6-phosphate dehydrogenase deficiency, and iron deficiency anaemia. Cannulation attempts caused bulla which progressed to ulceration. A pathergy phenomenon with high suspicion of pyoderma gangrenosum was postulated.
View Article and Find Full Text PDFRethinking the use of redox probes for the detection of electroactive proteins with electrochemical sensors modified with molecularly imprinted polymers.
Biosens Bioelectron
December 2024
Cnam, SATIE Laboratory, UMR, CNRS 8029, 292 rue Saint Martin, 75003, Paris, France. Electronic address:
This study aims to demonstrate that redox couples, regardless of their electrical charges, are unnecessary for detecting and quantifying electroactive proteins using an electrochemical sensor functionalized with a molecularly imprinted polymer. Our approach involved designing a polydopamine imprinted biosensor for detecting bovine serum albumin as the model protein. Electrochemical measurements were conducted in a phosphate-buffered solution (PBS) and solutions containing the negatively charged hexacyanoferrate, the neutral ferrocene, or the positively charged hexaammineruthenium (III) probes.
View Article and Find Full Text PDFLung Function Decline in Pulmonary Alveolar Microlithiasis.
Cureus
November 2024
Pulmonary Medicine, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ITA.
Pulmonary alveolar microlithiasis (PAM) is a rare lung disorder characterized by calcium phosphate microliths in the alveolar spaces. Autosomal recessive mutations on the SLC34A2 gene lead to altered type IIb sodium phosphate cotransporter in alveolar type-II cells of the lung, thus resulting in aggregations of microliths in the alveoli. To date, more than 1000 cases have been reviewed by expert pulmonary clinicians.
View Article and Find Full Text PDFOccurrence and ecological risks of antibiotics and antiparasitics in surface water in urban lakes in Hanoi city, Vietnam.
Environ Sci Pollut Res Int
December 2024
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay, Hanoi, Vietnam.
The presence of antibiotics in the environment is of significant concern due to their adverse effects on aquatic ecosystems. This study provides an assessment of potential ecological risks (RQ) associated with the concentrations of eight antibiotics and antiparasitics (amoxicillin-AMO, azithromycin-AZI, ciprofloxacine-CIP, ofloxacine-OFL, oxfendazole-OXF, lincomycin-LIN, sulfacetamide-SCE and sulfamethoxazole-SME) in the surface water of 13 urban lakes in Hanoi city, Vietnam during the period 2021-2023. The findings revealed considerable variations in the total concentrations of these 8 substances (T), ranging from below the method detection limit (< MDL) to 2240 ng L with an average of 330.
View Article and Find Full Text PDFPsoriatic skin-sensitive degradable mesoporous zinc phosphate microsphere as a photosensitizer in photodynamic therapy for anti-psoriasis.
Eur J Pharm Sci
December 2024
College of Pharmacy and Medical Technology, Putian University, Putian 351100, Fujian, China; Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Putian 351100, Fujian, China.
Blue light will be a promising alternative for photodynamic therapy in psoriasis, but the photosensitizer in vivo remains unexplored. Mesoporous zinc phosphate microparticle (MZP) was synthesized successfully in this study, as evidenced by XPS, XRD, and nitrogen adsorption experiments. Its psoriatic skin-sensitive property was corroborated by SEM and the higher cumulative release rate of that impregnated with curcumin (Cur) and glycyrrhizic acid (GA), namely Cur-GA-MZP, at pH 5.
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