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Novel antibodies detect nucleocytoplasmic O-fucose in protist pathogens, cellular slime molds, and plants.
bioRxiv
October 2024
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens GA.
Cellular adaptations to change often involve post-translational modifications of nuclear and cytoplasmic proteins. An example found in protists and plants is the modification of serine and threonine residues of dozens to hundreds of nucleocytoplasmic proteins with a single fucose (O-Fuc). A nucleocytoplasmic O-fucosyltransferase (OFT) occurs in the pathogen , the social amoeba , and higher plants, where it is called Spy because mutants have a spindly appearance.
View Article and Find Full Text PDFUnlabelled: , which are free-living amoebae, cause corneal inflammation (keratitis) and blindness, if not diagnosed and effectively treated. While trophozoites adhere to and damage the cornea, cysts, the walls of which contain cellulose and have two layers connected by conical ostioles, are the diagnostic form by microscopy of the eye or of corneal scrapings. We recently used structural and experimental methods to characterize cellulose-binding domains of Luke and Leo lectins, which are abundant in the inner layer and ostioles.
View Article and Find Full Text PDFMolecular identification of EhCRT gene Calreticulin isolated from children infected with Entamoeba histolytica.
J Pak Med Assoc
October 2024
Department of Biology, Iraqi University, Baghdad, Iraq.
Article Synopsis
- - The study aimed to detect the entamoeba histolytica gene and its immunogene calreticulin in stool samples from children suspected to be infected, conducted in two hospitals in Iraq from December 2020 to September 2021.
- - Out of 86 children tested, 71 (82.6%) were confirmed infected with entamoeba histolytica, with a notable prevalence in boys and a majority of cases within the 1-4 year age group; 44 cases detected the gene using conventional PCR and 36 expressed calreticulin using real-time PCR.
- - The findings suggest that polymerase chain reaction (PCR) is an effective diagnostic tool for detecting entamoeba histolytica
Identification and characterization of a carbohydrate recognition domain-like region in Gal/GalNAc lectin intermediate subunit.
Microbiol Spectr
November 2024
Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Article Synopsis
- Unlabelled is a protozoan parasite that causes human diseases like amebic colitis, and its ability to adhere to host cells is crucial for its pathogenicity.
- The study identified a carbohydrate-recognition domain (CRD)-like region in the intermediate subunit (Igl) of a Gal-/GalNAc-inhibitable lectin, which contains two key CXXC motifs important for recognizing carbohydrates.
- This research enhances our understanding of the molecular mechanisms behind the parasite's adhesion and could help identify potential drug targets for treatment.
Role of various virulence factors involved in the pathogenesis of Entamoeba histolytica.
Exp Parasitol
November 2024
Institute of Science, Nirma University, S-G Highway, Ahmedabad, 382481, India. Electronic address:
Developing countries continuously face challenges to get rid of amoebiasis, a protozoan disease caused by Entamoeba histolytica. Every year around 900 million people get affected by amoebiasis, among them only 10 % of people show the symptoms of the disease while 90 % of people do not show any symptoms but still, serve as carriers of the disease. Asymptomatic persons carry cysts of Entamoeba in their fecal matter, which is carried by house flies to contaminate the food and water.
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