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Galantamine Quantity and Alkaloid Profile in the Bulbs of and cultivars () Grown in Israel.
Metabolites
March 2021
Department of Natural Compounds and Analytical Chemistry, Migal-Galilee Research Institute, Kiryat Shmona 11016, Israel.
Alkaloids produced by the bulbs of the are a source of pharmaceutical compounds. The main alkaloid, galantamine, is a reversible acetylcholinesterase inhibitor and allosteric nicotinic receptor modulator, which slows cognitive and functional decline in mild to moderate dementia due to Alzheimer's disease. Having a complex stereochemistry, the organic synthesis of galantamine for pharmaceutical uses is highly challenging and not always economically viable, and it is therefore isolated from bulbs.
View Article and Find Full Text PDFAntineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies.
J Nat Prod
April 2012
Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, PO Box 871604, Tempe, Arizona 85287-1604, USA.
Bioassay-guided (cancer cell line) separation of an extract prepared from Narcissus cv. Ice Follies (from The Netherlands) led to the isolation of a new Amaryllidaceae isocarbostiryl, 3-epipancratistatin (1b), as well as narciclasine (2). This Narcissus cultivar was found to be a good source of narciclasine.
View Article and Find Full Text PDFBulbs of Narcissus were dissected into outer and inner scales, leaves, basal plate, flower, and bulbils to determine the distribution of alkaloids among different tissues. Quantitation of galanthamine as well as the other alkaloids was accomplished by capillary gas chromatography.
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