The problem was studied whether the activity of haloprogin is decreased in the presence of glucocorticoids (6-methyl-prednisolone hemisuccinate sodium; hydrocortisone) or in the presence of a bacteriostatic antibiotic (neomycin). Antifungal activity was determined by measuring changes in oxygen consumption of Saccharomyces cerevisiae in the resting phase. The results revealed that neither glucocorticoids in concentrations which activate yeast metabolism, nor neomycin impair the antifungal activity of haloprogin. Therefore, haloprogin may safely be used together with glucocorticoids and neomycin in topical therapy.
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